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Fig. 4 | BMC Musculoskeletal Disorders

Fig. 4

From: BADGE, a synthetic antagonist for PPARγ, prevents steroid-related osteonecrosis in a rabbit model

Fig. 4

Treatment with PPARγ inhibitors increased the serum osteocalcin (OCN) concentration, decreased the serum TRAP concentration and promoted expression of the osteogenic transcription factors. a The concentration of osteocalcin in the BADGE group was significantly increased compared with the model group. b In contrast to increased serum osteocalcin, the TRAP concentration was reduced in the BADGE group compared with the model group (n = 5). c-e BADGE treatment significantly increased protein and mRNA expression of the osteogenic transcription factors osteocalcin and Runx2 (n = 3). *P < 0.05 versus normal group; #P < 0.05 versus model group

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