Fig. 2
From: BADGE, a synthetic antagonist for PPARγ, prevents steroid-related osteonecrosis in a rabbit model
Treatment with PPARγ inhibitors reduced marrow adiposity and intraosseous pressure, and promoted femoral blood perfusion. a Compared with the model group, the average diameter of fat cells in the BADGE group decreased (n = 5). b The average fat cell area in the BADGE group was significantly reduced compared with the model group (n = 5). (c and d) BADGE treatment significantly decreased protein expression of the adipogenic transcription factor aP2 (n = 3). (e and f) Treatment with BADGE significantly decreased mRNA levels of the adipogenic transcription factors aP2 and CEBP (n = 3). g A lower intraosseous pressure was observed in the BADGE group compared with the model group (n = 5). h Blood perfusion, as indicated by dynamic contrast-enhanced MRIs, was significantly higher than that in the model group (n = 5). *P < 0.05 versus normal group; #P < 0.05 versus model group