Table 3 Histological evaluation using Mankin score and OARSI score for the 2-w OA and 4-w OA Models
From: Early detection of osteoarthritis in rabbits using MRI with a double-contrast agent
| Â | Mankin score | OARSI score | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
3 slices per rabbit | Â | Structure | Cells | Safranin-O staining | Tidemark | Total | Safranin-O staining | Structure | Chondrocyte density | Cluster formation | Total |
control (n = 1) | medial | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
lateral | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | |
2-w OA (n = 1) | medial | 0.0 ± 0.0 | 2.0 ± 0.0 | 1.0 ± 0.0 | 0.0 ± 0.0 | 3.0 ± 0.0 | 1.0 ± 0.0 | 0.0 ± 0.0 | 1.0 ± 0.0 | 1.0 ± 0.0 | 3.0 ± 0.0 |
lateral | 0.3 ± 0.6 | 2.0 ± 0.0 | 1.7 ± 0.6 | 0.0 ± 0.0 | 4.0 ± 1.0 | 2.3 ± 1.2 | 1.0 ± 1.7 | 2.0 ± 0.0 | 2.3 ± 1.2 | 7.7 ± 1.5 | |
4-w OA (n = 4) | medial | 3.0 ± 0.6 | 3.0 ± 0.0 | 2.6 ± 0.5 | 0.1 ± 0.3 | 8.7 ± 0.8 | 5.1 ± 1.0 | 4.9 ± 0.8 | 4.0 ± 0.0 | 1.0 ± 0.7 | 15.0 ± 1.5 |
lateral | 3.0 ± 0.9 | 3.0 ± 0.0 | 2.8 ± 0.4 | 0.1 ± 0.3 | 8.9 ± 1.1 | 5.5 ± 0.8 | 5.2 ± 0.3 | 4.0 ± 0.0 | 1.8 ± 0.6 | 16.4 ± 1.7 | |