Table 2 Perioperative details of the included studies

Gillespie [20]

TXA: 2 g in 100 ml NS for 5 min

Placebo: 100 ml NS for 5 min

N/S

DP

1) Hb < 7.0 g/dl

2) 7.1 g/dl < Hb < 9.0 g/dl + symptoms

N/S

Pauzenberger [23]

TXA: 1 g TXA intravenously in 100 ml NS, 2 doses

Placebo: 100 ml NS, 2 doses

TSA (Eclipse; Arthrex Inc., Naples, Florida)

RTSA (Delta Xtend; DePuy Synthes, Warsaw, Indiana)

DP

1) Hb < 8 g/dl

2) 8 g/dl < Hb < 10 g/dl + symptoms

Chemical prophylaxis (subcutaneous 40 mg of enoxaparin sodium + aspirin)

Vara [34]

TXA: 10 mg/kg IV, 1st dose within 60 mins before surgery, 2nd dose at wound closure

Placebo: NS

102 Non-cemented RTSA

(79 Zimmer; 11 DePuy; 4 Biomet; 2 Encore,)

DP

1) Hb < 7 g/dl

2) 7 g/dl < Hb < 9 g/dl + symptoms

Chemical prophylaxis (subcutaneous heparin + oral aspirin)

Mechanical prophylaxis (compression stockings)

Abildgaard [33]

TXA: 1 g IV at skin preparation

Placebo: no TXA

TSA (Bigliani/ Flatow Anatomical Total Shoulder; Zimmer, Warsaw, IN, USA)

RTSA (Trabecular Metal Inverse/Reverse Total Shoulder, Zimmer)

DP

1) Hb < 7 g/dl

2) 7 g/dl < Hb < 9 g/dl + symptoms

Chemical prophylaxis was not routinely used postoperatively

Friedman [19]

TXA: 20 mg/kg IV at skin preparation

Placebo: no TXA

RTSA: cemented; brand N/S

TSA: 90% non-cemented;

N/S

N/S

N/S

Kim [24]

TXA: 500 mg IV

25 DJO Reverse Shoulder Prosthesis; 16 Tornier reverse shoulder prosthesis; 7 Biomet Comprehensive Reverse Total Shoulder Replacement

DP

No absolute guideline

N/S