Skip to main content

Table 2 Perioperative details of the included studies

From: Tranexamic acid in total shoulder arthroplasty and reverse shoulder arthroplasty: a systematic review and meta-analysis

Author Year Intervention Prosthesis properties Approach Transfusion protocol Thromboprophylaxis
Gillespie [20] 2015 TXA: 2 g in 100 ml NS for 5 min
Placebo: 100 ml NS for 5 min
N/S DP 1) Hb < 7.0 g/dl
2) 7.1 g/dl < Hb < 9.0 g/dl + symptoms
N/S
Pauzenberger [23] 2017 TXA: 1 g TXA intravenously in 100 ml NS, 2 doses
Placebo: 100 ml NS, 2 doses
TSA (Eclipse; Arthrex Inc., Naples, Florida)
RTSA (Delta Xtend; DePuy Synthes, Warsaw, Indiana)
DP 1) Hb < 8 g/dl
2) 8 g/dl < Hb < 10 g/dl + symptoms
Chemical prophylaxis (subcutaneous 40 mg of enoxaparin sodium + aspirin)
Vara [34] 2017 TXA: 10 mg/kg IV, 1st dose within 60 mins before surgery, 2nd dose at wound closure
Placebo: NS
102 Non-cemented RTSA
(79 Zimmer; 11 DePuy; 4 Biomet; 2 Encore,)
DP 1) Hb < 7 g/dl
2) 7 g/dl < Hb < 9 g/dl + symptoms
Chemical prophylaxis (subcutaneous heparin + oral aspirin)
Mechanical prophylaxis (compression stockings)
Abildgaard [33] 2016 TXA: 1 g IV at skin preparation
Placebo: no TXA
TSA (Bigliani/ Flatow Anatomical Total Shoulder; Zimmer, Warsaw, IN, USA)
RTSA (Trabecular Metal Inverse/Reverse Total Shoulder, Zimmer)
DP 1) Hb < 7 g/dl
2) 7 g/dl < Hb < 9 g/dl + symptoms
Chemical prophylaxis was not routinely used postoperatively
Friedman [19] 2016 TXA: 20 mg/kg IV at skin preparation
Placebo: no TXA
RTSA: cemented; brand N/S
TSA: 90% non-cemented;
N/S N/S N/S
Kim [24] 2017 TXA: 500 mg IV 25 DJO Reverse Shoulder Prosthesis; 16 Tornier reverse shoulder prosthesis; 7 Biomet Comprehensive Reverse Total Shoulder Replacement DP No absolute guideline N/S
  1. DP Deltopectoral approach; Hb Hemoglobin; IV Intravenous; NS Normal saline; N/S Not shown; RTSA Reverse total shoulder arthroplasty; TSA Total shoulder arthroplasty; TXA Tranexamic acid