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Table 1 Characteristics of the included studies

From: Tranexamic acid in total shoulder arthroplasty and reverse shoulder arthroplasty: a systematic review and meta-analysis

Author Year Patients’ diagnosis Surgery Study design Enrolled sample number (M/F) Average age, years Outcome measurement Quality assessment
Gillespie [20] 2015 OA TSA 44
RTSA 67
Randomized controlled trial TXA 56 (27/29)
Placebo 55 (22/33)
TXA: 67.59
Placebo:66.45
Blood loss via drainage, Hb change, ETBL, transfusions, complications Detail shown in Fig. 2
Pauzenberger [20] 2017 Not mentioned TSA 26
RTSA 28
Randomized controlled trial TXA 27(20/7)
Placebo 27(18/9)
TXA: 70.3 ± 9.3
Placebo:71.3 ± 7.9
Blood loss via drainage, Hb/Hct change, ETBL, haematoma, complications Detail shown in Fig. 2
Vara [34] 2017 Massive rotator cuff deficiency ± glenohumeral arthrosis RTSA 102 Randomized controlled trial TXA 53(20/33)
Placebo 49(22/27)
TXA: 67 ± 9
Placebo:66 ± 9
Blood loss via drainage, Hb change, ETBL, operation time, hospital stay, transfusions, complications Detail shown in Fig. 2
Abildgaard [33] 2016 TSA:1 ON and 7 OA
RTSA:45 CTA, 34 massive cuff tear, 1 ON, 1RA, 11OA, and 2 fractures
TSA 77
RTSA 94
Retrospective cohort study TXA 77 (49/28)
Placebo 94 (51/43)
TSA: TXA: 70 (53–87)
Placebo:71 (58–87)
RTSA TXA: 74 (54–90)
Placebo: 76(54–89)
Blood loss via drainage, Hb/Hct change, ETBL, transfusions, complications 9a
Friedman [19] 2016 Not mentioned TSA 97
RTSA 97
Retrospective cohort study TXA 106 (46/60)
Placebo 88 (33/55)
not mentioned Hb/Hct, recover room time, operation time, hospital stay, transfusions, complications 8a
Kim [24] 2017 CTA RTSA 48 Retrospective cohort study TXA 24 (3/21)
Placebo 24 (6/18)
TXA: 73.2 ± 4.4
Placebo: 74.2 ± 4.4
Hb/Hct change, operation time, blood loss via drainage 8a
  1. CTA Cuff tear arthropathy; ETBL Estimated total blood loss; F Female; Hb Hemoglobin; Hct Hematocrit; M Male; OA Osteoarthritis; ON Osteonecrosis; RA Rheumatoid arthritis; RTSA Reverse total shoulder arthroplasty; TSA Total shoulder arthroplasty; TXA Tranexamic acid
  2. aQuality scores derived from the Newcastle-Ottawa Scale