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Fig. 9 | BMC Musculoskeletal Disorders

Fig. 9

From: Genetic polymorphisms in bone morphogenetic protein receptor type IA gene predisposes individuals to ossification of the posterior longitudinal ligament of the cervical spine via the smad signaling pathway

Fig. 9

The OC activity in transfected C3H10T1/2 cells. The OC activity levels were significantly increased in C3H10T1/2/pcDNA3.1/BMPR-IA (WT 1.01 ± 0.10 ng/mL, MT -349C > T 1.04 ± 0.12 ng/mL, MT 4A > C 1.02 ± 0.09 ng/mL, MT -349C > T and 4A > C 1.03 ± 0.13 ng/mL) cells compared to the control groups. n = 5, *p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA WT cells compared with C3H10T1/2 cells, *p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA WT cells compared with C3H10T1/2/pcDNA3.1 cells; *p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA MT -349C > T cells compared with C3H10T1/2 cells, *p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA MT -349C > T cells compared with C3H10T1/2/pcDNA3.1 cells; *p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA MT 4A > C cells compared with C3H10T1/2 cells, *p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA MT 4A > C cells compared with C3H10T1/2/pcDNA3.1 cells; *p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA MT -349C > T and 4A > C cells compared with C3H10T1/2 cells, *p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA MT -349C > T and 4A > C cells compared with C3H10T1/2/pcDNA3.1 cells. However, no significant differences were observed in OC activity between C3H10T1/2/pcDNA3.1/BMPRIA (WT 1.01 ± 0.10 ng/ml) cells and C3H10T1/2/pcDNA3.1/BMPRIA (MT -349C > T 1.04 ± 0.12 ng/mL, MT 4A > C 1.02 ± 0.09 ng/mL, MT -349C > T and 4A > C 1.03 ± 0.13 ng/mL) cells (n = 5)

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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