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Fig. 8 | BMC Musculoskeletal Disorders

Fig. 8

From: Genetic polymorphisms in bone morphogenetic protein receptor type IA gene predisposes individuals to ossification of the posterior longitudinal ligament of the cervical spine via the smad signaling pathway

Fig. 8

The ALP activity in transfected C3H10T1/2 cells. The ALP activity levels were significantly increased in C3H10T1/2/pcDNA3.1/BMPR-IA (MT -349C > T 30.56 ± 0.44 U/gprot, MT -349C > T and 4A > C 26.91 ± 0.41 U/gprot) cells compared to C3H10T1/2/pcDNA3.1/BMPR-IA (WT 23.67 ± 0.42 U/gprot) cells. n = 5, *p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA WT cells compared with C3H10T1/2 cells, *p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA WT cells compared with C3H10T1/2/pcDNA3.1 cells; **p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA MT -349C > T cells compared with C3H10T1/2 cells, **p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA MT -349C > T cells compared with C3H10T1/2/pcDNA3.1 cells; *p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA MT 4A > C cells compared with C3H10T1/2 cells, *p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA MT 4A > C cells compared with C3H10T1/2/pcDNA3.1 cells; **p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA MT -349C > T and 4A > C cells compared with C3H10T1/2 cells, **p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA MT -349C > T and 4A > C cells compared with C3H10T1/2/pcDNA3.1 cells; **p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA MT -349C > T cells compared with C3H10T1/2/pcDNA3.1/BMPRIA WT cells, **p < 0.001 C3H10T1/2/pcDNA3.1/BMPRIA MT -349C > T and 4A > C cells compared with C3H10T1/2/pcDNA3.1/BMPRIA WT cells. No differences in ALP activity in C3H10T1/2/pcDNA3.1/BMPR-IA (MT 4A > C 23.84 ± 0.42 U/gprot) cells were observed compared to the C3H10T1/2/pcDNA3.1/BMPR-IA (WT 23.67 ± 0.42 U/gprot) cells (n = 5)

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BMC Musculoskeletal Disorders

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