Identification of pain categories associated with change in pain in patients receiving placebo: data from two phase 3 randomized clinical trials in symptomatic knee osteoarthritis

Table 3 Correlations between baseline WOMAC scores, composite WOMAC scores and change in joint-space width (JSW) at year two

Variables		WOMAC Q1		WOMAC Q2		WOMAC Q3		WOMAC Q4		WOMAC Q5		WOMAC Weight-bearing		WOMAC idle		Total WOMAC pain score
Variables		adj	unadj	adj	unadj	adj	unadj	adj	unadj	adj	unadj	adj	unadj	adj	unadj	adj	unadj
Target chg in JSW yr. 2	Spearman	−0.03	− 0.01	− 0.10	−0.08	− 0.05	−0.03	0.00	0.00	0.04	0.05	−0.04	−0.02	− 0.02	−0.02	− 0.04	−0.02
	P	0.40	0.70	0.006	0.03	0.27	0.36	0.98	0.90	0.29	0.15	0.31	0.59	0.54	0.62	0.33	0.60
	N	771	771	771	771	771	771	771	771	771	771	771	771	771	771	771	771
Non Target chg in JSW yr. 2	Spearman	0.07	0.09	0.06	0.09	0.01	0.03	0.06	0.07	0.08	0.10	0.08	0.10	0.04	0.05	0.07	0.09
	P	0.07	0.02	0.09	0.02	0.71	0.40	0.10	0.05	0.02	0.007	0.03	0.007	0.27	0.14	0.05	0.01
	N	733	733	733	733	733	733	733	742	733	742	733	739	733	733	733	733

“Unadj” refers to unadjusted data. “Adj” is adjusted for Kellgren-Lawrence grade and Body Mass Index. Correlations with a p-value < 0.05 are highlighted in bold. WOMAC Western Ontario and McMaster’s Universities Arthritis Index

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