Fig. 1

Target knee (n = 771) and Non-target knee (n = 256) mean pain change from baseline in % over 24 months, normalized (0–100), by pain question (a) and category; Weight-bearing pain (WOMAC questions 1, 2 and 5), and non-weight-bearing pain (WOMAC questions 3 and 4) (b). Baseline values below 10 are set to 10 to reduce noise. Non-target knees were selected to include only those meeting the pain inclusion criteria of the target knee for comparability. c depicts mean change from baseline in %, adjusted for the estimated regression to the mean as listed in Table 2. Error bars are SEM. *: p < 0.05 ***: p < 0.001