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Table 2 Sensitivity analysis for the meta-analysis

From: Meta-analysis of serum C-reactive protein and cartilage oligomeric matrix protein levels as biomarkers for clinical knee osteoarthritis

  Outcomes No. of studies MD(95% CI) Heterogeneity test
P I2 (%)
KOA progress with CRP All studies 5 0.09 [−0.30, 0.13] < 0.00001 93.0
Haghighian, 2014 4 0.07 [− 0.04, 0.18] 0.02 70.0
Hosnijeh, 2016 4 −0.15 [− 0.77, 0.47] < 0.00001 94.0
Ramirez, 2014 4 −0.07 [− 0.29, 0.16] < 0.00001 94.0
Scorei, 2011 4 −0.15 [− 0.78, 0.49] < 0.00001 94.0
  Zhang, 2015 4 −0.20 [− 0.42, 0.02] < 0.00001 93.0
KOA incidence with CRP All studies 4 0.33 [0.04, 0.63] < 0.00001 96.0
Engstrom, 2009 3 0.39 [−0.08, 0.86] < 0.00001 97.0
Hosnijeh, 2016 3 0.45 [−0.05, 0.95] < 0.00001 97.0
Kerkhof, 2010 3 0.46 [0.06, 0.86] < 0.00001 97.0
Zhang, 2015 3 0.09 [−0.03, 0.21] 0.01 76.0
KOA pain with CRP All studies 3 1.60 [0.52, 2.67] 0.001 85.0
Nielsen, 2014 2 1.69 [−0.02, 3.40] 0.03 78.0
Sowers, 2002 2 1.13 [0.44, 1.82] 0.49 0.0
Stannus, 2012 2 1.88 [0.76, 3.00] 0.003 89.0
  1. KOA knee osteoarthritis, CRP C-reactive protein