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Table 2 Sensitivity analysis for the meta-analysis

From: Meta-analysis of serum C-reactive protein and cartilage oligomeric matrix protein levels as biomarkers for clinical knee osteoarthritis

 

Outcomes

No. of studies

MD(95% CI)

Heterogeneity test

P

I2 (%)

KOA progress with CRP

All studies

5

0.09 [−0.30, 0.13]

< 0.00001

93.0

Haghighian, 2014

4

0.07 [− 0.04, 0.18]

0.02

70.0

Hosnijeh, 2016

4

−0.15 [− 0.77, 0.47]

< 0.00001

94.0

Ramirez, 2014

4

−0.07 [− 0.29, 0.16]

< 0.00001

94.0

Scorei, 2011

4

−0.15 [− 0.78, 0.49]

< 0.00001

94.0

 

Zhang, 2015

4

−0.20 [− 0.42, 0.02]

< 0.00001

93.0

KOA incidence with CRP

All studies

4

0.33 [0.04, 0.63]

< 0.00001

96.0

Engstrom, 2009

3

0.39 [−0.08, 0.86]

< 0.00001

97.0

Hosnijeh, 2016

3

0.45 [−0.05, 0.95]

< 0.00001

97.0

Kerkhof, 2010

3

0.46 [0.06, 0.86]

< 0.00001

97.0

Zhang, 2015

3

0.09 [−0.03, 0.21]

0.01

76.0

KOA pain with CRP

All studies

3

1.60 [0.52, 2.67]

0.001

85.0

Nielsen, 2014

2

1.69 [−0.02, 3.40]

0.03

78.0

Sowers, 2002

2

1.13 [0.44, 1.82]

0.49

0.0

Stannus, 2012

2

1.88 [0.76, 3.00]

0.003

89.0

  1. KOA knee osteoarthritis, CRP C-reactive protein