| |
Outcomes
|
No. of studies
|
MD(95% CI)
|
Heterogeneity test
|
|---|
|
P
|
I2 (%)
|
|---|
|
KOA progress with CRP
|
All studies
|
5
|
0.09 [−0.30, 0.13]
|
< 0.00001
|
93.0
|
|
Haghighian, 2014
|
4
|
0.07 [− 0.04, 0.18]
|
0.02
|
70.0
|
|
Hosnijeh, 2016
|
4
|
−0.15 [− 0.77, 0.47]
|
< 0.00001
|
94.0
|
|
Ramirez, 2014
|
4
|
−0.07 [− 0.29, 0.16]
|
< 0.00001
|
94.0
|
|
Scorei, 2011
|
4
|
−0.15 [− 0.78, 0.49]
|
< 0.00001
|
94.0
|
| |
Zhang, 2015
|
4
|
−0.20 [− 0.42, 0.02]
|
< 0.00001
|
93.0
|
|
KOA incidence with CRP
|
All studies
|
4
|
0.33 [0.04, 0.63]
|
< 0.00001
|
96.0
|
|
Engstrom, 2009
|
3
|
0.39 [−0.08, 0.86]
|
< 0.00001
|
97.0
|
|
Hosnijeh, 2016
|
3
|
0.45 [−0.05, 0.95]
|
< 0.00001
|
97.0
|
|
Kerkhof, 2010
|
3
|
0.46 [0.06, 0.86]
|
< 0.00001
|
97.0
|
|
Zhang, 2015
|
3
|
0.09 [−0.03, 0.21]
|
0.01
|
76.0
|
|
KOA pain with CRP
|
All studies
|
3
|
1.60 [0.52, 2.67]
|
0.001
|
85.0
|
|
Nielsen, 2014
|
2
|
1.69 [−0.02, 3.40]
|
0.03
|
78.0
|
|
Sowers, 2002
|
2
|
1.13 [0.44, 1.82]
|
0.49
|
0.0
|
|
Stannus, 2012
|
2
|
1.88 [0.76, 3.00]
|
0.003
|
89.0
|
- KOA knee osteoarthritis, CRP C-reactive protein
