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Table 2 Study characteristics

From: The efficacy of multiple versus single hyaluronic acid injections: a systematic review and meta-analysis

Study Characteristics
Trial ID Country Study Design Funded By Industry N Treatment Arms Number of injections OA Severity (KL) Visit closest to 26 weeks (weeks)
      Treatment Control    
Altman, 2004 USA, Canada, Sweden Double-blinded RCT Yes 346 Durolane Saline 1 2,3,4 26
Altman, 2009 USA Double-blinded RCT Yes 588 Euflexxa Saline 3 2,3 26
Arden, 2014 Sweden, German, UK Double-blinded RCT Yes 218 Durolane Saline 1 2,3 6
Brandt, 2001 USA Double-blinded RCT Yes 226 Orthovisc Saline 3 NR 27
Chevalier, 2010 UK, France, Czech Republic, Germany, Belgium, Netherlands Double-blinded RCT Yes 253 Synvisc Saline 1 2,3,4 26
Creamer, 1994 UK Single-blinded RCT Yes 12 Hyalgan Saline 5 2,3,4 5
Day, 2004 Australia Double-blinded RCT Yes 240 Artzal Saline 5 NR 18
DeCaria, 2012 Canada Double-blinded RCT Yes 30 Low MW HA Sham HA 3 NR 26
Diracoglu, 2009 Turkey Double-blinded RCT No 63 Synvisc Saline 3 2,3 4
Dixon, 1988 UK Double-blinded RCT Yes 63 Hyalgan 1/100 Hyalgan 1–11 NR 25
Henderson, 1994 UK Double-blinded RCT No 91 Hyalgan Saline 5 2,3,4 5
Huang, 2011 Taiwan Double-blinded RCT Yes 200 Hyalgan Saline 5 2,3 25
Huskisson, 1999 UK Single-blinded RCT No 100 Hyalgan Saline 5 2,3 26
Jorgensen, 2010 Denmark Double-blinded RCT No 337 Hyalgan Saline 5 NR 26
Karlsson, 2002 Sweden Double-blinded RCT Yes 246 Synvisc Saline 3 NR 26
Kotevoglu, 2006 Turkey Double-blinded RCT No 78 Synvisc Saline 3 2,3,4 27
Lohmander, 1996 Denmark, Finland, Norway, Sweden Double-blinded RCT Yes 240 Artzal Saline 5 NR 20
Lundsgaard, 2008 UK, Netherlands Double-blinded RCT No 308 Hyalgan Saline 4 1,2,3,4 26
Navarro-Sarabia 2011 Spain Double-blinded RCT Yes 306 Adant Saline 5 2,3 28
Neustadt, 2005 USA, Canada Double-blinded RCT Yes 229 Orthovisc Arthrocentesis 4 1,2,3 22
Petrella, 2006 Canada Double-blinded RCT Yes 106 HA sodium salt Saline 3 1,2,3 12
Petrella, 2008 Canada Double-blinded RCT No 200 Synvisc Saline 3 1,2 16
Pham, 2004 France Double-blinded RCT No 301 NRD101 HA Saline 3 1,2,3,4 52
Puhl, 1993 Germany Double-blinded RCT Yes 209 Artzal 1/100 ARTZ 5 NR 14
Scale, 1994 USA Double-blinded RCT Yes 80 Synvisc Saline 2, 3 2,3,4 12
Sezgin, 2005 Turkey Single-blinded RCT No 41 Orthovisc Saline 3 2,3 4
Strand, 2012 Japan Double-blinded RCT Yes 379 Gel-ONE Saline 1 1,2,3 13
Tamir, 2001 Israel Single-blinded RCT No 49 BioHY Saline 5 2,3,4 20
van der Weegen, 2015 Netherlands Double-blinded RCT Yes 196 Fermathron plus Saline 3 1,2,3 26
Wobig, 1998 Germany Double-blinded RCT Yes 110 Synvisc Saline 3 1,2,3 26