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Table 2 Study characteristics

From: The efficacy of multiple versus single hyaluronic acid injections: a systematic review and meta-analysis

Study Characteristics

Trial ID

Country

Study Design

Funded By Industry

N

Treatment Arms

Number of injections

OA Severity (KL)

Visit closest to 26 weeks (weeks)

     

Treatment

Control

   

Altman, 2004

USA, Canada, Sweden

Double-blinded RCT

Yes

346

Durolane

Saline

1

2,3,4

26

Altman, 2009

USA

Double-blinded RCT

Yes

588

Euflexxa

Saline

3

2,3

26

Arden, 2014

Sweden, German, UK

Double-blinded RCT

Yes

218

Durolane

Saline

1

2,3

6

Brandt, 2001

USA

Double-blinded RCT

Yes

226

Orthovisc

Saline

3

NR

27

Chevalier, 2010

UK, France, Czech Republic, Germany, Belgium, Netherlands

Double-blinded RCT

Yes

253

Synvisc

Saline

1

2,3,4

26

Creamer, 1994

UK

Single-blinded RCT

Yes

12

Hyalgan

Saline

5

2,3,4

5

Day, 2004

Australia

Double-blinded RCT

Yes

240

Artzal

Saline

5

NR

18

DeCaria, 2012

Canada

Double-blinded RCT

Yes

30

Low MW HA

Sham HA

3

NR

26

Diracoglu, 2009

Turkey

Double-blinded RCT

No

63

Synvisc

Saline

3

2,3

4

Dixon, 1988

UK

Double-blinded RCT

Yes

63

Hyalgan

1/100 Hyalgan

1–11

NR

25

Henderson, 1994

UK

Double-blinded RCT

No

91

Hyalgan

Saline

5

2,3,4

5

Huang, 2011

Taiwan

Double-blinded RCT

Yes

200

Hyalgan

Saline

5

2,3

25

Huskisson, 1999

UK

Single-blinded RCT

No

100

Hyalgan

Saline

5

2,3

26

Jorgensen, 2010

Denmark

Double-blinded RCT

No

337

Hyalgan

Saline

5

NR

26

Karlsson, 2002

Sweden

Double-blinded RCT

Yes

246

Synvisc

Saline

3

NR

26

Kotevoglu, 2006

Turkey

Double-blinded RCT

No

78

Synvisc

Saline

3

2,3,4

27

Lohmander, 1996

Denmark, Finland, Norway, Sweden

Double-blinded RCT

Yes

240

Artzal

Saline

5

NR

20

Lundsgaard, 2008

UK, Netherlands

Double-blinded RCT

No

308

Hyalgan

Saline

4

1,2,3,4

26

Navarro-Sarabia 2011

Spain

Double-blinded RCT

Yes

306

Adant

Saline

5

2,3

28

Neustadt, 2005

USA, Canada

Double-blinded RCT

Yes

229

Orthovisc

Arthrocentesis

4

1,2,3

22

Petrella, 2006

Canada

Double-blinded RCT

Yes

106

HA sodium salt

Saline

3

1,2,3

12

Petrella, 2008

Canada

Double-blinded RCT

No

200

Synvisc

Saline

3

1,2

16

Pham, 2004

France

Double-blinded RCT

No

301

NRD101 HA

Saline

3

1,2,3,4

52

Puhl, 1993

Germany

Double-blinded RCT

Yes

209

Artzal

1/100 ARTZ

5

NR

14

Scale, 1994

USA

Double-blinded RCT

Yes

80

Synvisc

Saline

2, 3

2,3,4

12

Sezgin, 2005

Turkey

Single-blinded RCT

No

41

Orthovisc

Saline

3

2,3

4

Strand, 2012

Japan

Double-blinded RCT

Yes

379

Gel-ONE

Saline

1

1,2,3

13

Tamir, 2001

Israel

Single-blinded RCT

No

49

BioHY

Saline

5

2,3,4

20

van der Weegen, 2015

Netherlands

Double-blinded RCT

Yes

196

Fermathron plus

Saline

3

1,2,3

26

Wobig, 1998

Germany

Double-blinded RCT

Yes

110

Synvisc

Saline

3

1,2,3

26