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Table 3 HR-pQCT Disease (Rheumatoid Arthritis vs No Rheumatoid Arthritis) Main Effects Summary

From: Micro-structural bone changes in early rheumatoid arthritis persist over 1-year despite use of disease modifying anti-rheumatic drug therapy

Region of Interest (ROI) Parameter Outcome Variable RA Participants NRA Participants P Value Group Diff
Value (%)
Mean SEM Mean SEM (2-tailed) (RA-NRA)
UUD (n = 46, 23 pairs) Volumetric Bone Density Cortical Material Bone Mineral Density (mgHA/cm3) TMDcort 946.54 8.61 945.36 7.67 0.903 1.19 (0.1%)
Cortical Apparent Bone Mineral Density (mgHA/cm3) BMDcort 779.71 15.64 782.14 14.98 0.889 −2.43 (−0.3%)
Trabecular Apparent Bone Mineral Density (mgHA/cm3) BMDtrab 159.84 6.99 188.15 7.19 0.001 −28.31 (−15.0%)
Cortical Microstructure Cortical Thickness (mm) - Direct CtTh 0.73 0.03 0.69 0.03 0.241 0.05 (6.7%)
Cortical Thickness _ SD (mm) CtThSd 0.30 0.01 0.27 0.01 0.047 0.03 (9.3%)
Cortical Bone Volume Fraction (%) BV/TVcort 91.55% 0.76% 91.56% 0.98% 0.993 −0.01 (0.0%)
Cortical Porosity (%) CtPo 1.76% 0.22% 1.71% 0.24% 0.830 0.04 (2.6%)
Trabecular Microstructure Trabecular Bone Volume Fraction (%) -Direct BV/TVtrab 26.08% 0.92% 29.66% 0.88% 0.001 −3.57 (−12.1%)
Trabecular Connective Density (mm4) TbCD 4.14 0.22 4.76 0.20 0.005 −0.62 (−13.0%)
Trabecular Structural Model Index (0–3) SMI 1.94 0.08 1.61 0.08 0.002 0.33 (20.8%)
Trabecular Number (1/mm) TbN 1.91 0.06 2.06 0.05 0.016 −0.15 (−7.2%)
Trabecular Thickness (mm) - Direct TbNSd 0.195 0.002 0.199 0.002 0.130 −0.005 (−2.3%)
Trabecular Thickness _SD (mm) TbTh 0.07 0.00 0.07 0.00 0.419 0.001 (1.9%)
Trabecular Separation (mm) TbSp 0.52 0.02 0.46 0.01 0.006 0.05 (11.9%)
Trabecular Separation_SD (mm) TbSpSd 0.22 0.02 0.18 0.01 0.023 0.04 (22.9%)
MH3 (n = 44, 22 pairs) Volumetric Bone Density Cortical Material Bone Mineral Density (mgHA/cm3) TMDcort 815.17 10.67 840.60 9.70 0.055 −25.43 (−3.0%)
Cortical Apparent Bone Mineral Density (mgHA/cm3) BMDcort 537.77 15.52 589.12 16.17 0.012 −51.35 (−8.7%)
Trabecular Apparent Bone Mineral Density (mgHA/cm3) BMDtrab 234.04 8.13 262.57 7.89 0.004 −28.53 (−10.9%)
Cortical Microstructure Cortical Thickness (mm) - Direct CtTh 0.35 0.02 0.39 0.02 0.107 −0.04 (−9.2%)
Cortical Thickness _ SD (mm) CtThSd 0.22 0.02 0.24 0.02 0.285 −0.03 (−11.1%)
Cortical Bone Volume Fraction (%) BV/TVcort 78.70% 1.11% 81.79% 1.11% 0.020 −3.09 (−3.8%)
Cortical Porosity (%) CtPo 0.92% 0.07% 1.04% 0.07% 0.284 0.12 (−11.2%)
Trabecular Microstructure Trabecular Bone Volume Fraction (%) - Direct BV/TVtrab 35.03% 0.90% 38.14% 0.74% 0.002 −3.10 (−8.1%)
Trabecular Connective Density (mm4) TbCD 6.45 0.32 7.05 0.37 0.210 −0.61 (−8.6%)
Trabecular Structural Model Index (0–3) SMI 0.95 0.10 0.58 0.10 0.005 0.37 (63.5%)
Trabecular Number (1/mm) TbN 2.18 0.07 2.34 0.05 0.051 0.16 (−6.9%)
Trabecular Thickness (mm) - Direct TbNSd 0.206 0.003 0.208 0.003 0.651 - 0.002 (−0.8%)
Trabecular Thickness _SD (mm) TbTh 0.07 0.00 0.07 0.00 0.182 0.002 (3.4%)
Trabecular Separation (mm) - Direct TbSp 0.44 0.02 0.39 0.01 0.011 0.05 (12.6%)
Trabecular Separation_SD (mm) - Direct TbSpSd 0.24 0.02 0.18 0.01 0.012 0.06 (32.7%)
MH2 (n = 44, 22 pairs) Volumetric Bone Density Cortical Material Bone Mineral Density (mgHA/cm3) TMDcort 800.40 9.53 832.97 8.52 0.003 −32.57 (−3.9%)
Cortical Apparent Bone Mineral Density (mgHA/cm3) BMDcort 547.07 14.90 607.46 16.58 0.002 −60.39 (−9.9%)
Trabecular Apparent Bone Mineral Density (mgHA/cm3) BMDtrab 227.13 8.17 268.49 9.01 0.000 −41.37 (−15.4%)
Cortical Microstructure Cortical Thickness (mm) - Direct CtTh 0.35 0.01 0.38 0.01 0.090 −0.03 (−7.4%)
Cortical Thickness _ SD (mm) CtThSd 0.20 0.01 0.19 0.01 0.937 0.001 (0.6%)
Cortical Bone Volume Fraction (%) BV/TVcort 80.03% 1.21% 83.77% 1.26% 0.016 −3.74 (−4.5%)
Cortical Porosity (%) CtPo 0.92% 0.06% 0.96% 0.06% 0.626 −0.04 (−4.3%)
Trabecular Microstructure Trabecular Bone Volume Fraction (%) BV/TVtrab 33.69% 0.91% 38.17% 0.87% 0.0002 --4.48 (11.7%)
Trabecular Connective Density (mm4) TbCD 6.24 0.28 6.94 0.33 0.117 −0.70 (−10.1%)
Trabecular Structural Model Index (0–3) SMI 1.06 0.10 0.58 0.10 0.0001 0.48 (84.1%)
Trabecular Number (1/mm) TbN 2.08 0.07 2.28 0.06 0.014 −0.20 (−9.0%)
Trabecular Thickness (mm) - Direct TbNSd 0.203 0.003 0.210 0.004 0.090 −0.01 (−3.5%)
Trabecular Thickness _SD (mm) TbTh 0.07 0.00 0.07 0.00 0.445 −0.003 (−3.9%)
Trabecular Separation (mm) TbSp 0.47 0.02 0.40 0.01 0.006 0.06 (16.0%)
Trabecular Separation_SD (mm) TbSpSd 0.27 0.02 0.20 0.02 0.008 0.07 (35.2%)
  1. BOLD: P < 0.05; Italics: p ≤ 0.10
  2. NOTE: No adjustment for multiple independent statistical analyses of HR-pQCT outcomes