Table 3 HR-pQCT Disease (Rheumatoid Arthritis vs No Rheumatoid Arthritis) Main Effects Summary
Region of Interest (ROI) | Parameter | Outcome | Variable | RA Participants | NRA Participants | P Value | Group Diff Value (%) | ||
|---|---|---|---|---|---|---|---|---|---|
Mean | SEM | Mean | SEM | (2-tailed) | (RA-NRA) | ||||
UUD (n = 46, 23 pairs) | Volumetric Bone Density | Cortical Material Bone Mineral Density (mgHA/cm3) | TMDcort | 946.54 | 8.61 | 945.36 | 7.67 | 0.903 | 1.19 (0.1%) |
Cortical Apparent Bone Mineral Density (mgHA/cm3) | BMDcort | 779.71 | 15.64 | 782.14 | 14.98 | 0.889 | −2.43 (−0.3%) | ||
Trabecular Apparent Bone Mineral Density (mgHA/cm3) | BMDtrab | 159.84 | 6.99 | 188.15 | 7.19 | 0.001 | −28.31 (−15.0%) | ||
Cortical Microstructure | Cortical Thickness (mm) - Direct | CtTh | 0.73 | 0.03 | 0.69 | 0.03 | 0.241 | 0.05 (6.7%) | |
Cortical Thickness _ SD (mm) | CtThSd | 0.30 | 0.01 | 0.27 | 0.01 | 0.047 | 0.03 (9.3%) | ||
Cortical Bone Volume Fraction (%) | BV/TVcort | 91.55% | 0.76% | 91.56% | 0.98% | 0.993 | −0.01 (0.0%) | ||
Cortical Porosity (%) | CtPo | 1.76% | 0.22% | 1.71% | 0.24% | 0.830 | 0.04 (2.6%) | ||
Trabecular Microstructure | Trabecular Bone Volume Fraction (%) -Direct | BV/TVtrab | 26.08% | 0.92% | 29.66% | 0.88% | 0.001 | −3.57 (−12.1%) | |
Trabecular Connective Density (mm4) | TbCD | 4.14 | 0.22 | 4.76 | 0.20 | 0.005 | −0.62 (−13.0%) | ||
Trabecular Structural Model Index (0–3) | SMI | 1.94 | 0.08 | 1.61 | 0.08 | 0.002 | 0.33 (20.8%) | ||
Trabecular Number (1/mm) | TbN | 1.91 | 0.06 | 2.06 | 0.05 | 0.016 | −0.15 (−7.2%) | ||
Trabecular Thickness (mm) - Direct | TbNSd | 0.195 | 0.002 | 0.199 | 0.002 | 0.130 | −0.005 (−2.3%) | ||
Trabecular Thickness _SD (mm) | TbTh | 0.07 | 0.00 | 0.07 | 0.00 | 0.419 | 0.001 (1.9%) | ||
Trabecular Separation (mm) | TbSp | 0.52 | 0.02 | 0.46 | 0.01 | 0.006 | 0.05 (11.9%) | ||
Trabecular Separation_SD (mm) | TbSpSd | 0.22 | 0.02 | 0.18 | 0.01 | 0.023 | 0.04 (22.9%) | ||
MH3 (n = 44, 22 pairs) | Volumetric Bone Density | Cortical Material Bone Mineral Density (mgHA/cm3) | TMDcort | 815.17 | 10.67 | 840.60 | 9.70 | 0.055 | −25.43 (−3.0%) |
Cortical Apparent Bone Mineral Density (mgHA/cm3) | BMDcort | 537.77 | 15.52 | 589.12 | 16.17 | 0.012 | −51.35 (−8.7%) | ||
Trabecular Apparent Bone Mineral Density (mgHA/cm3) | BMDtrab | 234.04 | 8.13 | 262.57 | 7.89 | 0.004 | −28.53 (−10.9%) | ||
Cortical Microstructure | Cortical Thickness (mm) - Direct | CtTh | 0.35 | 0.02 | 0.39 | 0.02 | 0.107 | −0.04 (−9.2%) | |
Cortical Thickness _ SD (mm) | CtThSd | 0.22 | 0.02 | 0.24 | 0.02 | 0.285 | −0.03 (−11.1%) | ||
Cortical Bone Volume Fraction (%) | BV/TVcort | 78.70% | 1.11% | 81.79% | 1.11% | 0.020 | −3.09 (−3.8%) | ||
Cortical Porosity (%) | CtPo | 0.92% | 0.07% | 1.04% | 0.07% | 0.284 | 0.12 (−11.2%) | ||
Trabecular Microstructure | Trabecular Bone Volume Fraction (%) - Direct | BV/TVtrab | 35.03% | 0.90% | 38.14% | 0.74% | 0.002 | −3.10 (−8.1%) | |
Trabecular Connective Density (mm4) | TbCD | 6.45 | 0.32 | 7.05 | 0.37 | 0.210 | −0.61 (−8.6%) | ||
Trabecular Structural Model Index (0–3) | SMI | 0.95 | 0.10 | 0.58 | 0.10 | 0.005 | 0.37 (63.5%) | ||
Trabecular Number (1/mm) | TbN | 2.18 | 0.07 | 2.34 | 0.05 | 0.051 | 0.16 (−6.9%) | ||
Trabecular Thickness (mm) - Direct | TbNSd | 0.206 | 0.003 | 0.208 | 0.003 | 0.651 | - 0.002 (−0.8%) | ||
Trabecular Thickness _SD (mm) | TbTh | 0.07 | 0.00 | 0.07 | 0.00 | 0.182 | 0.002 (3.4%) | ||
Trabecular Separation (mm) - Direct | TbSp | 0.44 | 0.02 | 0.39 | 0.01 | 0.011 | 0.05 (12.6%) | ||
Trabecular Separation_SD (mm) - Direct | TbSpSd | 0.24 | 0.02 | 0.18 | 0.01 | 0.012 | 0.06 (32.7%) | ||
MH2 (n = 44, 22 pairs) | Volumetric Bone Density | Cortical Material Bone Mineral Density (mgHA/cm3) | TMDcort | 800.40 | 9.53 | 832.97 | 8.52 | 0.003 | −32.57 (−3.9%) |
Cortical Apparent Bone Mineral Density (mgHA/cm3) | BMDcort | 547.07 | 14.90 | 607.46 | 16.58 | 0.002 | −60.39 (−9.9%) | ||
Trabecular Apparent Bone Mineral Density (mgHA/cm3) | BMDtrab | 227.13 | 8.17 | 268.49 | 9.01 | 0.000 | −41.37 (−15.4%) | ||
Cortical Microstructure | Cortical Thickness (mm) - Direct | CtTh | 0.35 | 0.01 | 0.38 | 0.01 | 0.090 | −0.03 (−7.4%) | |
Cortical Thickness _ SD (mm) | CtThSd | 0.20 | 0.01 | 0.19 | 0.01 | 0.937 | 0.001 (0.6%) | ||
Cortical Bone Volume Fraction (%) | BV/TVcort | 80.03% | 1.21% | 83.77% | 1.26% | 0.016 | −3.74 (−4.5%) | ||
Cortical Porosity (%) | CtPo | 0.92% | 0.06% | 0.96% | 0.06% | 0.626 | −0.04 (−4.3%) | ||
Trabecular Microstructure | Trabecular Bone Volume Fraction (%) | BV/TVtrab | 33.69% | 0.91% | 38.17% | 0.87% | 0.0002 | --4.48 (11.7%) | |
Trabecular Connective Density (mm4) | TbCD | 6.24 | 0.28 | 6.94 | 0.33 | 0.117 | −0.70 (−10.1%) | ||
Trabecular Structural Model Index (0–3) | SMI | 1.06 | 0.10 | 0.58 | 0.10 | 0.0001 | 0.48 (84.1%) | ||
Trabecular Number (1/mm) | TbN | 2.08 | 0.07 | 2.28 | 0.06 | 0.014 | −0.20 (−9.0%) | ||
Trabecular Thickness (mm) - Direct | TbNSd | 0.203 | 0.003 | 0.210 | 0.004 | 0.090 | −0.01 (−3.5%) | ||
Trabecular Thickness _SD (mm) | TbTh | 0.07 | 0.00 | 0.07 | 0.00 | 0.445 | −0.003 (−3.9%) | ||
Trabecular Separation (mm) | TbSp | 0.47 | 0.02 | 0.40 | 0.01 | 0.006 | 0.06 (16.0%) | ||
Trabecular Separation_SD (mm) | TbSpSd | 0.27 | 0.02 | 0.20 | 0.02 | 0.008 | 0.07 (35.2%) | ||