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Table 1 Baseline characteristics at inclusion and predictors of knee replacement, univariate and multivariate analyses

From: Risk factors for joint replacement in knee osteoarthritis; a 15-year follow-up study

 

Total

Knee replacement

Unadjusted

Adjusteda

Variable

(n = 100)

Yes (n = 66)

No (n = 34)

OR (95% CI)

p value

OR (95% CI)

p value

Female, % (no.)

64% (64)

68% (45)

56% (19)

1.0 (0.9 – 1.0)

0.52

  

Age (years), mean (SD)

62.0 (10.4)

61.3 (10.0)

63.4 (10.9)

1.0 (0.9 – 1.0)

0.34

  

BMI grade, mean (SD)

2.2 (0.9)

2.2 (0.9)

2.0 (0.9)

1.2 (0.8 – 2.0)

0.41

  

WOMAC, mean (SD):

- Pain

184 (89)

196 (95)

161 (71)

1.0 (1.0 – 1.0)

0.07

  

- Stiffness

81 (45)

87(46)

67 (40)

1.3 (1.01 – 1.6)c

0.04

1.3 (1.01 – 1.7)c

0.04

- Function

657 (319)

692 (332)

588 (281)

1.0 (1.0 – 1.0)

0.13

  

- Total

922 (427)

976 (446)

817 (366)

1.0 (1.0 – 1.0)

0.08

  

Hyalgan %, (no.)

48% (48)

50% (33)

44% (15)

1.3 (0.6 – 2.9)

0.58

  

JSN grade, mean (SD)

1.7 (1.0)

2.0 (0.9)

1.0 (0.8)

3.6 (2.1 - 6.2)

<0.001

5.0 (2.6 - 9.9)

<0.001

Radiological sum score, mean (SD)

5.0 (2.6)

5.8 (2.3)

3.4 (2.5)

1.5 (1.3 - 1.9)

<0.001

1.7 (1.3 - 2.1)

<0.001

BML grade, mean (SD)b, d

2.1 (1.4)

2.4 (1.5)

1.4 (0.9)

2.1 (1.2 – 3.7)

0.006

2.3 (1.3 – 4.0)

0.005

Synovitis grade, mean (SD)b, e

2.6 (1.0)

2.9 (0.9)

2.0 (1.1)

2.7 (1.5 – 4.7)

0.001

2.8 (1.5 – 5.2)

0.001

Effusion grade, mean (SD)b, f

2.4 (1.5)

2.7 (1.6)

1.7 (1.1)

1.9 (1.2 – 3.0)

0.005

1.9 (1.2 – 3.1)

0.006

  1. OR odds ratio, CI confidence interval, No. number, SD standard deviation, BMI body mass index, WOMAC Western Ontario and McMaster Universities OA index, JSN joint space narrowing, BML bone marrow lesion
  2. aAdjusted for sex, age and BMI; b Based on 83 participants with MRI scans and tibiofemoral osteoarthritis; c Logistic regression performed after ordering data into a ten point ordinal scale (Grade 1 = 0 – 10, grade 2 = 11 – 20 etc.); d Ordered into a ten point ordinal scale (Grade 1 = 0 - 10% BML, grade 2 = >10 - 20% BML etc.); eOrdered into a five point ordinal scale (Grade 1 = 0 - <5; grade 2 = 5 - <10 etc.); f Ordered into an eight point ordinal scale (Grade 1 = 0 - < 5; grade 2 = 5 - <10 etc.) (maximum effusion score = 38)