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Table 1 Presence and relative risk of progression of cartilage damage, Hoffa-synovitis and effusion-synovitis in different knee compartments for all visits combined from baseline to 12 months

From: Structural effects of intra-articular TGF-β1 in moderate to advanced knee osteoarthritis: MRI-based assessment in a randomized controlled trial

   Number of subjects who had follow-up visits and included in analysis Number of subjects with MRI progression Analysis adjusted for age and gender
Compartment Definition T a P T P RR (95% CI) p-value
Knee Progression in any subregion 133 71 46 (34.6%) 34 (47.9%) 0.7 (0.5,1.1) 0.077
  Delta Subregion > 0 123 71 43 (35.0%) 32 (45.1%) 0.8 (0.5,1.2) 0.207
  Delta Sum > 0 123 71 26 (21.1%) 23 (32.4%) 0.6 (0.3,1.2) 0.176
Lateral TFJ Progression in any subregion 133 71 20 (15.0%) 12 (16.9%) 0.8 (0.3,1.9) 0.617
  Delta Subregion > 0 128 71 20 (15.6%) 12 (16.9%) 0.8 (0.4,1.9) 0.680
  Delta Sum > 0 128 71 13 (10.2%) 10 (14.1%) 0.7 (0.2,1.9) 0.434
Medial TFJ Progression in any subregion 133 71 23 (17.3%) 12 (16.9%) 1.1 (0.5,2.5) 0.767
  Delta Subregion > 0 133 71 23 (17.3%) 12 (16.9%) 1.1(0.5,2.5) 0.767
  Delta Sum > 0 133 71 16 (12.0%) 5 (7.0%) 1.9(0.5,7.2) 0.345
PF Progression in any subregion 131 71 18(13.7%) 16(22.5%) 0.6(0.3,1.3) 0.176
  Delta Subregion > 0 128 71 17(13.3%) 15(21.1%) 0.6(0.3,1.3) 0.210
  Delta Sum > 0 128 71 10(7.8%) 10(14.1%) 0.5(0.2,1.9) 0.327
MRI feature Definition T P T P RR (95% CI) p-value
Hoffa-synovitis/ Effusion-synovitis combined Any worsening 136 71 13 (9.6%) 15 (21.1%) 0.5 (0.2,1.2) 0.115
Hoffa-synovitis Any worsening 133 71 4 (3.0%) 5 (7.0%) 0.3 (0.1,1.8) 0.200
Effusion-synovitis Any worsening 136 71 12 (8.8%) 11 (15.5%) 0.6 (0.2,2.0) 0.428
  1. T treatment group, P placebo group, TFJ tibiofemoral joint, RR relative risk
  2. aNote: We excluded knees with MRI score missing in any subregion at either baseline or follow-up visit when defining delta subregion and delta sum, but did not exclude these knees when defining progression in any subregion. So N used for progressoin in any subregion was equal to or larger than N used in the two delta approaches