Table 1 Presence and relative risk of progression of cartilage damage, Hoffa-synovitis and effusion-synovitis in different knee compartments for all visits combined from baseline to 12 months
Number of subjects who had follow-up visits and included in analysis | Number of subjects with MRI progression | Analysis adjusted for age and gender | |||||
|---|---|---|---|---|---|---|---|
Compartment | Definition | T a | P | T | P | RR (95% CI) | p-value |
Knee | Progression in any subregion | 133 | 71 | 46 (34.6%) | 34 (47.9%) | 0.7 (0.5,1.1) | 0.077 |
Delta Subregion > 0 | 123 | 71 | 43 (35.0%) | 32 (45.1%) | 0.8 (0.5,1.2) | 0.207 | |
Delta Sum > 0 | 123 | 71 | 26 (21.1%) | 23 (32.4%) | 0.6 (0.3,1.2) | 0.176 | |
Lateral TFJ | Progression in any subregion | 133 | 71 | 20 (15.0%) | 12 (16.9%) | 0.8 (0.3,1.9) | 0.617 |
Delta Subregion > 0 | 128 | 71 | 20 (15.6%) | 12 (16.9%) | 0.8 (0.4,1.9) | 0.680 | |
Delta Sum > 0 | 128 | 71 | 13 (10.2%) | 10 (14.1%) | 0.7 (0.2,1.9) | 0.434 | |
Medial TFJ | Progression in any subregion | 133 | 71 | 23 (17.3%) | 12 (16.9%) | 1.1 (0.5,2.5) | 0.767 |
Delta Subregion > 0 | 133 | 71 | 23 (17.3%) | 12 (16.9%) | 1.1(0.5,2.5) | 0.767 | |
Delta Sum > 0 | 133 | 71 | 16 (12.0%) | 5 (7.0%) | 1.9(0.5,7.2) | 0.345 | |
PF | Progression in any subregion | 131 | 71 | 18(13.7%) | 16(22.5%) | 0.6(0.3,1.3) | 0.176 |
Delta Subregion > 0 | 128 | 71 | 17(13.3%) | 15(21.1%) | 0.6(0.3,1.3) | 0.210 | |
Delta Sum > 0 | 128 | 71 | 10(7.8%) | 10(14.1%) | 0.5(0.2,1.9) | 0.327 | |
MRI feature | Definition | T | P | T | P | RR (95% CI) | p-value |
Hoffa-synovitis/ Effusion-synovitis combined | Any worsening | 136 | 71 | 13 (9.6%) | 15 (21.1%) | 0.5 (0.2,1.2) | 0.115 |
Hoffa-synovitis | Any worsening | 133 | 71 | 4 (3.0%) | 5 (7.0%) | 0.3 (0.1,1.8) | 0.200 |
Effusion-synovitis | Any worsening | 136 | 71 | 12 (8.8%) | 11 (15.5%) | 0.6 (0.2,2.0) | 0.428 |