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Table 1 Arthritis score, plasma cytokines, and Treg proportions in CIA mice in response to treatment with celecoxib or L161982

From: L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels

  Mouse groups (n = 6)
Model Control CIA-model
Blank PBS Celecoxib L161982
Arthritis score(day 35) 0 7.00 ± 2.90 6.67 ± 2.34 3.67 ± 1.21 4.83 ± 1.17
Synovitis score 0 3.50 ± 0.54 3.83 ± 1.17 1.56 ± 0.8 1.83 ± 0.75
Il-17 (pg/ml) 14.38 ± 3.2 27.51 ± 8.1* 28.51 ± 6.4 10.65 ± 4.8# 13.52 ± 3.9#
MCP-1 (pg/ml) 13.1 ± 2.8 30.2 ± 3.4* 30.2 ± 3.4 14.98 ± 3.8# 15.80 ± 2.1#
Treg/ CD4+ T cell (%)
 Lymph node 4.7 ± 0.5 3.31 ± 0.36* 3.01 ± 0.96 3.25 ± 1.6 4.21 ± 0.52#
 Spleen 2.8 ± 0.5 1.67 ± 0.14* 1.7 ± 0.33 1.75 ± 0.73 2.63 ± 0.41#
  1. Data are mean ± SD; “CIA” means collagen induced arthritis; “Blank” means CIA model without any drug treatment; “PBS” means phosphate buffered saline. “*” means p < 0.01 compared to Model control group; “#” means p < 0.01 compared to PBS group; Additional file 1
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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