|
Mouse groups (n = 6)
|
---|
Model Control
|
CIA-model
|
---|
Blank
|
PBS
|
Celecoxib
|
L161982
|
---|
Arthritis score(day 35)
|
0
|
7.00 ± 2.90
|
6.67 ± 2.34
|
3.67 ± 1.21
|
4.83 ± 1.17
|
Synovitis score
|
0
|
3.50 ± 0.54
|
3.83 ± 1.17
|
1.56 ± 0.8
|
1.83 ± 0.75
|
Il-17 (pg/ml)
|
14.38 ± 3.2
|
27.51 ± 8.1*
|
28.51 ± 6.4
|
10.65 ± 4.8#
|
13.52 ± 3.9#
|
MCP-1 (pg/ml)
|
13.1 ± 2.8
|
30.2 ± 3.4*
|
30.2 ± 3.4
|
14.98 ± 3.8#
|
15.80 ± 2.1#
|
Treg/ CD4+ T cell (%)
|
Lymph node
|
4.7 ± 0.5
|
3.31 ± 0.36*
|
3.01 ± 0.96
|
3.25 ± 1.6
|
4.21 ± 0.52#
|
Spleen
|
2.8 ± 0.5
|
1.67 ± 0.14*
|
1.7 ± 0.33
|
1.75 ± 0.73
|
2.63 ± 0.41#
|
- Data are mean ± SD; “CIA” means collagen induced arthritis; “Blank” means CIA model without any drug treatment; “PBS” means phosphate buffered saline. “*” means p < 0.01 compared to Model control group; “#” means p < 0.01 compared to PBS group; Additional file 1