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Fig. 3 | BMC Musculoskeletal Disorders

Fig. 3

From: Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage

Fig. 3

ELISA analysis for dose-dependency study of ADAMTS-5 and -9 produced by cultured human synovial cells. a: ELISA analysis for the dose-dependency response of ADAMTS-5 to Hb. Confluent cells were incubated with various concentrations of Hb (0, 25, 50, and100 μg/ml), then the conditioned media were collected at 24 h. The level of ADAMTS-5 significantly increased even at 25 μg/ml compared with the control (p < 0.05). b: ELISA analysis for the dose-dependent response of ADAMTS-9 to Hb. ADAMTS-9 was highly expressed at 25, 50, and 100 μg/ml significantly after Hb stimulation (p < 0.05). There were no Hb dose-dependent effect for ADAMTS-5 and -9 expression by cultured human synovial cells

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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