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Fig. 1 | BMC Musculoskeletal Disorders

Fig. 1

From: Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage

Fig. 1

Flowchart of the present study. Human knee synovial tissue was obtained from five patients under arthroscopic surgery. After primary culture, several doses of Hb-treatment were administered. The culture medium was used for Western blotting and ELISA analysis for time-course and dose-dependent studies. Cells were used for real-time PCR analysis of the time-course study. The results shown are typical of several independent experiments (N = 6). Hb: hemoglobin. ELISA: Enzyme-Linked Immunosorbent Assay. Real-time PCR: Real-time polymerase chain reaction

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