Exclusion criteria
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Age ≥ 91 yearsa
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Actual use of bone sparing drugsb
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Use of bone sparing drugs during the preceding 5 years
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Terminal illness
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Not being able to participate in the study or no consent
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Weight > 135 kgc
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Corticosteroid use of ≥7.5 mg prednison equivalent per day
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aCalculation of FRAX (fracture risk assessment tool) is not possible for this age category
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bBisphosphonates, strontiumranelate, estrogens, selective estrogen receptor modulators, parathyroid hormone analogues or denosumab. If new bone sparing drugs will become available during the trial, they were added to the exclusion list
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cMaximum weight for dual-energy x-ray absorptiometry measurement