Table 1 Measurement of domains and data collection time points for questionnaire data. (* Clinical assessments will be conducted in a sub-sample of participants at baseline with follow-up assessments at Year 3 for all participants and incident KP cases recruited at Year 1 and Year 3)

Demographic & Occupation Data

Date of birth, Gender, Height & Weight & list of main occupations (duration and whether it was part time or full time)

Medical & Medication

History

Diagnosis of any comorbidities such as diabetes, stroke, fibromyalgia.

Trauma or significant injury to the lower limbs.

All current medication including supplements and alternative medications.

Knee Pain

Knee Pain presence, diagnosis of knee OA, any surgical interventions, any treatments for knee pain,

ICOAP (Intermittent and Constant OA Pain)

Pain Detect Questionnaire

Knee Alignment

Current and Constitutional alignment using line drawings

Hands

2D4D ratio; OA nodes; family history of OA nodes and knee or hip joint replacement

Body Pain

Body Pain Mannequin for current body pain

Quality of Pain (severity)

Psychosocial Factors

Hospital Anxiety & Depression Score

Sleep scale from Medical Outcomes Survey (from Year 1)

Conscientiousness Test (from Year 1)

Fibromyalgia Mannequin (from Year 1)

Life Orientation Test (LOT) (from Year 1)

Quality of Life

SF – 12

Illness Attitude Scale

Pain Catastrophising Scale

Blood & Urine Sample Collection

Fasting Biomarker Sample collection

Ultrasound

Quantitative Sensory Testing

Radiographs

Bilateral radiographs consisting of PA view of the tibiofemoral compartment and skyline view of the patellofemoral compartment using a Rosen template (standardised views).

Gait Assessment

Gaitrite and RS Scan for walking speed, cadence, step length, step width and static and dynamic balance

Muscle Strength

JAMAR hand dynomometer & Nicholas Muscle Testers for hand grip strength and quadriceps/ hip abductor strength respectively.