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Table 1 Clinical features and imaging examinations of 12 patients with TIO

From: Treatment and outcomes of tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors: retrospective review of 12 patients

Case

Gender

Duration (y)

Calcium

(mmol/L)

25-(OH)D3

(ng/ml)

PTH (pg/ml)

Phosphorous (mmol/L)

ALP (IU/L)

24hUP (mmol)

RP (d)

PE

Localization methods

Further localization

Tumor location

Pathology

OCT

PET/CT

MRI/CT

US

1

F

4

2.14

21.92

74.1

0.53

94

18.33

7

N

P

P

P

lumbar vertebrae 1

PMT

1a

F

0.5

1.98

13.13

59.5

0.45

89

18.32

3

N

P

P

P

lumbar vertebrae 1

PMT

2

F

4

2.01

14.09

69.6

0.33

95

35.82

2

N

N

P

P

intra sacral canal

PMT

3

F

0.5

2.27

11.27

67.1

0.69

176

16.97

3

N

P

right ilium

PMT

4

F

5

2.14

18.77

54.3

0.38

264

4.98

3

N

P

P

P

soft tissue of left thigh

PMT

5

M

3

2.12

16.33

71

0.24

96

18.76

3

N

P

P

soft tissue of left nasal cavity

PMT

6

M

2

2.18

16.72

41.9

0.41

237

37.26

3

N

P

P

P

soft tissue of left thigh

PMT

7

F

3

2.05

4.22

57

0.44

98

20.08

3

N

N

P

P

left maxillary bone

PMT

8

M

4

2.02

7.38

56.5

0.51

236

33.64

3

N

N

P

P

right lateral proximal femur

PMT

9

M

7

2.26

14.78

70.2

0.44

479

9.62

3

P

N

P

P

left palm soft tissue

PMT

10

F

2

2.42

6.66

56.3

0.36

162

10.01

2

P

P

P

P

mons veneris area

soft tissue

PMT

11

M

10

2.65

23.06

172

0.28

87

8.50

not recover-ed

N

P

P

P

P

left popliteal fossa, left proximal tibiofibula soft tissue, right adductor magnus

PMT

12

M

3

2.39

14.18

74.9

0.45

233

43.42

3

N

N

P

P

the 5th rib on the left side

PMT

Summary

6/6

3.7 ± 2.6

2.20 ± 0.19

14.04 ± 5.64

71.1 ± 31.8

0.42 ± 0.12

180.5 ± 112.3

21.21 ± 12.40

3 (2, 7)

2

7/12

8/8

12

5

2 in head, 2 in thoracic and lumber region, 3 in pelvis, 4 in lower limbs, 1 in upper limbs

 
  1. a: Patient 1 recurrence; 24-h UP 24 h urine phosphorus, RP recovery time of serum phosphorus after surgery, OCT 99mTc-octreotide, PE physical examination, US ultrasonography;
  2. P positive, N negative; −, not performed
  3. Values with normal distribution are expressed as the mean ± SD; values with skew distribution are expressed as median (range)