BMC Musculoskeletal Disorders

Table 2 Ratios on neuroimmune expression between hip osteoarthritis and controls according to the sample

From: Neuroimmune expression in hip osteoarthritis: a systematic review

	SF	SM			Cartilage				Serum	Bone							Immune Cells		Blood
	Abrams, 2014 [10]	Hulejova, 2007 [7]	Takeshita, 2012 [23]	Saxler, 2005 [5]	Hulejova, 2007 [7]	Hashimoto, 2013 [14]	Verdier, 2003 [24]	Pombo-Suarez, 2009 [20]	Hulejova, 2007 [7]	Hulejova, 2007 [7]	Koorts, 2012 [16]	Shi, 2002 [22]	Kumarasinghe, 2012 [17]	Sanchez-Sabaté, 2009 [21]	Hopwood, 2007 [15]	Lavigne, 2004 [18]	Dallos, 2009 [11]	Granchi, 2003 [13]	Granchi 2006 [12]	Pape, 2000 [19]
BAFF																	↑↑*
BMP-1														=^b
BMP-5															↓↓↓↓
BMP-6														=^b
CGRP			↑↑↑*	↑↑↑↑*
GM-CSF											↓↓							↑↑↑↑
ICAM																↑↑
ICAM-3															↑↑↑↑
IFN-γ	↑↑										↓↓↓							↑↑↑↑
IL-10		↑↑↑↑*			↑↑↑↑*				↓↓*	↑↑↑↑*	↓↓↓↓*							↓↓↓↓*
Il-12											↓↓↓↓
IL-1Rα	↓↓↓↓
IL-1α		↑↑↑↑			↑↑↑*				↓↓↓	↑↑↑↑*
Il-1β	↓					=^b					↓↓	=^b
IL-2											↓							↑↑↑↑*
IL-4											↓							↓↓↓↓*
IL-5											↓↓↓↓
IL-6	↑↑↑↑										↑	↑*^b			↑↑↑↑			↓		↑↑↑↑*
IL-8		↑↑↑↑*			↓	=^b			↓	↑↑↑↑*	↑
MCP-1	↑
MIP-1β	↑↑↑↑
NF-Kb			↑↑↑*
OPG																			↑↑↑*
PDGF-ββ	↓↓↓↓
PGE-2												↑*^b
RANKL																			↓↓
RANTES	↓↓↓
SP				↑↑↑↑*
TGF-β											↑↑↑*		=^b
TGF-β1							↑↑↑	↑↑↑/↑↑^a							↑↑↑↑
TGF-β2							=	↑↑↑*^a						↑*^b
TGF-β3							↑↑	↑↑↑↑/↑↑↑^a						↑*^b
TGF-βR1							↑/=							=^b	↓↓↓↓
TNF-α	↓↓↓↓	↑↑↑↑	↑↑↑*		↑↑↑				↑↑*	↑↑↑↑*	↓							↓↓↓↓		↑↑
TuJ-1			↑↑*
VEGF	↑↑↑
VEGF-b															↑↑↑↑
VEGF-c															↑↑↑↑

Ratios were computed as times raised: ↑: 1–1.25; ↑↑: 1.25–1.50;↑↑↑: 1.50–2; ↑↑↑↑: >2; and times decreased: ↓: 1–0.8; ↓↓: 0.8–0.67; ↓↓↓: 0.67–0.5; ↓↓↓↓: <0.5. When values are not available a single arrow (when statistically significant) or = (when non significant) was displayed. Data on statistically significance weren’t available or statistically significant, unless indicated as *p < 0.05
SF synovial fluid, SM synovial membrane, Blood Whole Blood, hOA hip Osteoarthritis, C Controls. ^aPCR and Immunohistochemestry. ^bValues not available

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ISSN: 1471-2474

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