Fig. 6From: Plasminogen activator inhibitor-1 deficiency enhances subchondral osteopenia after induction of osteoarthritis in miceEffects of PAI-1 deficiency on osteoclast formation from mouse bone marrow cells. After bone marrow cells obtained from WT and PAI-1 KO mice cultured with M-CSF (50 ng/ml) for 3 days, cells were treated with or without IL-1β in the presence of M-CSF (50 ng/ml) and RANKL (50 ng/ml) for 3 days. Then, TRAP-positive MNCs were counted. Data represent the mean ± SEM. n = 6 for each group. **p < 0.01Back to article page