Skip to main content
Fig. 5 | BMC Musculoskeletal Disorders

Fig. 5

From: Effects of hyaluronic acid combined with anti-inflammatory drugs compared with hyaluronic acid alone, in clinical trials and experiments in osteoarthritis: a systematic review and meta-analysis

Fig. 5

Forest plots of cartilage structure synthesis and degradation in vitro: (a) ACAN and COL2A1 anabolic gene expression in chondrocytes or cartilage explants, comparing HA + AI and HA; (b) ADAMTS5, COX-2, IL-1β, MMP2, MMP3, and MMP13 catabolic gene expression in chondrocytes or cartilage explants, comparing HA + AI and HA; (c) GAG remaining in chondrocyte pellets or cartilage explants, comparing HA + AI and HA. ACAN, aggrecan gene; AI, anti-inflammatory drugs; CI, confidence interval; COL2A1, collagen type II alpha 1 gene; GAG, glycosaminoglycans; HA, hyaluronic acid; RE, random effects model

Back to article page