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Table 3 The allele frequency of SNPs covering AKAP2

From: Lack of association between AKAP2 and the susceptibility of adolescent idiopathic scoliosis in the Chinese population

SNP

MA

MAF

P

OR (95% CI)

Patients

Controls

rs7022209

A

0.459

0.470

0.47

0.96 (0.85–1.08)

rs6477728

G

0.473

0.484

0.43

0.95 (0.85–1.07)

rs2769147

G

0.422

0.428

0.67

0.98 (0.87–1.10)

rs2795054

A

0.212

0.197

0.21

1.10 (0.95–1.26)

rs2795055

G

0.459

0.470

0.48

0.96 (0.86–1.08)

rs2182815

A

0.266

0.276

0.42

0.95 (0.83–1.08)

rs1887521

G

0.346

0.354

0.60

0.97 (0.86–1.09)

rs10980040

A

0.335

0.343

0.60

0.97 (0.86–1.09)

rs10980042

T

0.331

0.341

0.45

0.95 (0.85–1.08)

rs10980043

A

0.331

0.341

0.45

0.95 (0.85–1.08)

rs13289532

C

0.330

0.341

0.43

0.95 (0.84–1.08)

rs10759366

C

0.317

0.324

0.63

0.97 (0.86–1.10)

rs10759367

C

0.318

0.324

0.65

0.97 (0.86–1.10)

rs10980055

G

0.338

0.317

0.13

1.10 (0.97–1.24)

rs730973

A

0.346

0.330

0.23

1.08 (0.95–1.22)

rs1327785

A

0.336

0.346

0.46

0.96 (0.85–1.08)

rs10759369

A

0.319

0.324

0.71

0.98 (0.86–1.10)

rs12237683

T

0.336

0.346

0.48

0.96 (0.85–1.08)

rs10980064

C

0.318

0.324

0.62

0.97 (0.86–1.10)

rs3983508

C

0.346

0.330

0.25

1.07 (0.95–1.21)

rs4295727

T

0.328

0.314

0.30

1.07 (0.94–1.21)

rs2795058

A

0.273

0.285

0.37

0.94 (0.83–1.07)

rs7871857

C

0.147

0.142

0.59

1.05 (0.89–1.23)

rs12001151

C

0.156

0.140

0.13

1.13 (0.95–1.33)

rs2418050

A

0.483

0.476

0.63

1.03 (0.92–1.15)

rs7864423

A

0.149

0.135

0.16

1.13 (0.96–1.33)

rs7867595

A

0.149

0.134

0.16

1.12 (0.95–1.32)

rs1125416

A

0.147

0.142

0.57

1.05 (0.89–1.23)

rs2900498

C

0.100

0.091

0.34

1.10 (0.90–1.33)

rs875926

T

0.271

0.265

0.65

1.03 (0.91–1.17)

rs2769151

T

0.348

0.347

0.97

1.00 (0.89–1.13)

rs10816895

G

0.255

0.251

0.78

1.02 (0.89–1.16)

rs913361

T

0.256

0.267

0.41

0.95 (0.83–1.08)

rs17794822

A

0.181

0.178

0.80

1.02 (0.88–1.18)

rs10980086

C

0.276

0.268

0.51

1.04 (0.92–1.19)

rs10980091

C

0.468

0.454

0.34

1.06 (0.94–1.19)

rs12338023

G

0.193

0.188

0.70

1.03 (0.89–1.19)

rs2769143

C

0.227

0.228

0.95

1.00 (0.87–1.14)

rs2769145

G

0.087

0.084

0.72

1.04 (0.85–1.27)

rs17794870

T

0.178

0.177

0.88

1.01 (0.87–1.18)

rs9299178

G

0.192

0.194

0.86

0.99 (0.85–1.14)

rs2479311

A

0.238

0.239

0.99

1.00 (0.87–1.14)

rs10816902

C

0.193

0.193

0.94

0.99 (0.86–1.15)

rs10980097

C

0.192

0.188

0.67

1.03 (0.89–1.20)

rs7044189

C

0.364

0.351

0.35

1.06 (0.94–1.19)

rs13299632

C

0.281

0.286

0.70

0.98 (0.86–1.11)

rs7042517

T

0.439

0.446

0.65

0.97 (0.87–1.10)

rs2479314

G

0.306

0.316

0.44

0.95 (0.84–1.08)

rs16914570

T

0.112

0.104

0.40

1.08 (0.90–1.30)

rs2418060

A

0.444

0.449

0.70

0.98 (0.87–1.10)

rs2418061

T

0.441

0.447

0.66

0.97 (0.87–1.09)

rs7040294

T

0.444

0.449

0.73

0.98 (0.87–1.10)

rs1475433

T

0.445

0.447

0.92

0.99 (0.89–1.12)

rs16914573

A

0.111

0.102

0.35

1.09 (0.91–1.31)

rs13283300

C

0.205

0.200

0.70

1.03 (0.89–1.19)

rs9408826

A

0.156

0.140

0.13

1.14 (0.97–1.34)

rs12237174

A

0.252

0.239

0.31

1.07 (0.94–1.22)

rs10980109

G

0.149

0.139

0.29

1.09 (0.93–1.29)

rs7040787

A

0.278

0.275

0.79

1.02 (0.90–1.16)

rs4978856

T

0.239

0.249

0.40

0.94 (0.83–1.08)

rs7849107

A

0.251

0.249

0.89

1.01 (0.88–1.15)

rs2095094

C

0.079

0.091

0.16

0.86 (0.70–1.06)

rs1981035

A

0.238

0.249

0.37

0.94 (0.82–1.08)

rs1981036

A

0.240

0.248

0.56

0.96 (0.84–1.10)

rs877640

G

0.083

0.083

0.98

1.00 (0.81–1.23)

rs11999319

G

0.234

0.237

0.81

0.98 (0.86–1.13)

rs2277146

C

0.453

0.444

0.57

1.03 (0.92–1.16)

rs10120878

C

0.078

0.070

0.32

1.12 (0.90–1.39)

rs4978862

T

0.141

0.140

0.90

1.01 (0.86–1.19)

rs4978864

G

0.413

0.418

0.75

0.98 (0.87–1.10)

rs4978865

T

0.400

0.408

0.60

0.97 (0.86–1.09)

rs1930249

G

0.403

0.407

0.75

0.98 (0.87–1.10)

rs12683699

G

0.228

0.234

0.62

0.97 (0.84–1.11)

rs10739286

T

0.174

0.168

0.60

1.04 (0.89–1.21)

rs10980133

T

0.348

0.345

0.80

1.02 (0.90–1.15)

rs10816909

A

0.111

0.103

0.38

1.09 (0.90–1.31)

rs4978411

T

0.224

0.217

0.56

1.04 (0.91–1.20)

rs10217743

A

0.198

0.183

0.18

1.10 (0.95–1.28)

rs12000943

G

0.344

0.343

0.95

1.00 (0.89–1.13)

rs10739287

A

0.237

0.241

0.74

0.98 (0.85–1.12)

rs10816913

T

0.238

0.242

0.75

0.98 (0.86–1.12)

rs7864336

G

0.455

0.444

0.48

1.04 (0.93–1.17)

rs260193

A

0.367

0.358

0.51

1.04 (0.92–1.17)

rs7024673

A

0.235

0.250

0.23

0.92 (0.81–1.05)

rs260202

G

0.406

0.394

0.38

1.05 (0.94–1.19)

rs260221

C

0.449

0.437

0.41

1.05 (0.94–1.18)

rs10980164

T

0.381

0.394

0.38

0.95 (0.84–1.07)

rs10980169

A

0.063

0.078

0.05

0.80 (0.64–1.00)

rs2017393

G

0.378

0.387

0.51

0.96 (0.85–1.08)

rs2017392

G

0.378

0.387

0.53

0.96 (0.86–1.08)

rs2017219

C

0.389

0.395

0.68

0.98 (0.87–1.10)

rs541471

G

0.119

0.126

0.45

0.93 (0.78–1.11)

rs545955

C

0.456

0.437

0.21

1.08 (0.96–1.21)

rs552182

T

0.119

0.128

0.36

0.92 (0.77–1.10)

rs539817

T

0.448

0.433

0.32

1.06 (0.95–1.19)

rs475530

G

0.449

0.431

0.23

1.07 (0.96–1.21)

rs487013

C

0.485

0.464

0.14

1.09 (0.97–1.22)

rs491730

C

0.110

0.120

0.29

0.91 (0.76–1.09)

rs10759388

A

0.388

0.405

0.24

0.93 (0.83–1.05)

rs528811

T

0.365

0.382

0.23

0.93 (0.83–1.05)

rs10816924

A

0.182

0.165

0.12

1.13 (0.97–1.31)

rs10980210

G

0.286

0.307

0.10

0.90 (0.79–1.02)

rs7871428

G

0.199

0.173

0.02

1.19 (1.02–1.38)

rs4978870

A

0.214

0.221

0.61

0.96 (0.84–1.11)

rs17806457

A

0.205

0.208

0.81

0.98 (0.85–1.13)

rs2418071

C

0.076

0.071

0.48

1.08 (0.87–1.35)

rs10980217

C

0.201

0.203

0.87

0.99 (0.95–1.14)

rs3739455

G

0.173

0.176

0.80

0.98 (0.84–1.14)

rs16914814

C

0.177

0.182

0.67

0.97 (0.83–1.12)

rs1023180

A

0.114

0.109

0.58

1.05 (0.88–1.26)

rs10980229

A

0.417

0.408

0.54

1.04 (0.92–1.17)

rs10980231

C

0.154

0.151

0.76

1.03 (0.87–1.20)

rs4978877

G

0.501

0.491

0.48

1.04 (0.93–1.17)

rs10980234

G

0.287

0.279

0.56

1.04 (0.91–1.18)

rs10816929

G

0.308

0.305

0.84

1.01 (0.89–1.15)

rs1331310

C

0.229

0.228

0.95

1.01 (0.88–1.15)

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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