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Table 1 The standardized multimodal protocol for perioperative pain medication

From: Which patient-specific and surgical characteristics influence postoperative pain after THA in a fast-track setting?

Timing Medication
2 h before surgery Paracetamol (acetaminophen) 1000 mg per os.
Celecoxib (Celebrex®) a 400 mg per os.
Gabapentin 600 mg per os.
Just before surgery Dexamethasone 0.15 mg/kg iv. b
Esketamine 15 mg iv.
4 h after surgery Paracetamol (acetaminophen) 1000 mg per os.
8 h after surgery Paracetamol (acetaminophen) 1000 mg per os.
Gabapentin 300 mg per os.
Before the night Tramadol 100 mg supp.
Day 1 Paracetamol (acetaminophen) 1000 mg per os 4 times a day.
Celecoxib (Celebrex®) a 200 mg per os in the morning.
Gabapentin 300 mg per os in the morning.
After day 1 Paracetamol (acetaminophen) 1000 mg per os 4 times a day (with a maximum of 2 weeks).
Celecoxib (Celebrex®) a 200 mg per os in the morning (until 2 weeks after surgery).
Rescue medication Celecoxib (Celebrex®) a 200 mg per os extra after the first night Piritramid (Dipidolor®) 10 mg im, which could be repeated every 4 h.
  1. The standardized multimodal protocol for perioperative pain medication was determined based on literature [7,8,9,10,11,12]
  2. aIn combination with celecoxib (Celebrex®) all patients will receive omeprazol 20 mg per os once a day as prophylaxis. When the patient was already using a proton pomp inhibitor before admittance no omeprazol was administered
  3. bDexamethasone solution in 50cm3 saline is administered slowly to avoid adverse side effects like severe perianal pain