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Table 5 Quantitative RT-PCR fold differences between untreated patients with polymyalgia rheumatica (PMR) and non-PMR controls, and fold changes between treated and untreated PMR patients

From: Gene expression profiling in patients with polymyalgia rheumatica before and after symptom-abolishing glucocorticoid treatment

Gene symbol

Fold differencesb

Fold changesc

(probe name)

qRT-PCR

Microarraya

qRT-PCR

Microarraya

Genes that differed in microarray testing in at least one comparison

BDNF

+1.90*

+1.80 *

−1.58 **

−3.1 **

COL5A1

−1.33 ns

−1.30 **

+1.73 ns

+2.30 ns

EIF4B

+1.63 p = 0.0504

+1.30 *

−1.23 *

−1.30 *

MARK4

+1.32 ns

+1.30 **

−1.24 *

−1.15 ns

MTFP1

+1.00 ns

−1.50 **

+1.33 *

+1.30 *

NPM1

+1.38 **

+1.30 *

−1.09 ns

−1.22 *

PRSS23

−1.21 ns

−1.40 *

+1.27 ns

+1.51 *

TFRC

−1.63 ns

−3.00 *

+1.17 ns

+1.76 ns

TUBD1

+1.26 **

+1.30 **

−1.08 ns

−1.40 **

Genes that did not differ in microarray testing

ACTA1

(203872_at)

−1.03 ns

−1.02 ns

1.06 ns

+1.00 ns

DESa

(216947_at

202222_s_at

214027_x_at)

+1.16 ns

+1.00 ns

−1.07 ns

+1.00 ns

IL6

(205207_at)

+4.54 *

+1.02 ns

−3.25 *

+1.02 ns

TNFA

(207113_s_at)

+1.31 ns

+1.00 ns

−1.31 ns

−1.00 ns

TUBA8

(220069_at)

−1.02 ns

−1.02 ns

+1.10 ns

+1.00 ns

  1. qRT-PCR quantitative real-time PCR
  2. * p < 0.05. ** p < 0.01. ns, not statistically significant. Data are geometric means
  3. a Microarray numbers were calculated as the mean of the individual probe values
  4. b + and −, expression levels were higher and lower, respectively, in patients with polymyalgia rheumatica than in controls before treatment with prednisolone
  5. c + and −, expression levels increased and decreased, respectively, in patients with polymyalgia rheumatica after treatment with prednisolone