Table 4 Genes the expression levels of which differed between untreated patients with polymyalgia rheumaticaand untreated controls (FD), and which responded to prednisolone treatment in the patients (FC) (44 genes)
Gene symbol | Gene name | FDa | p | FCb | p |
|---|---|---|---|---|---|
BDNF | brain-derived neurotrophic factor | +1.8 | 0.016 | −3.1 | 0.001 |
SVIP | small VCP/p97-interacting protein | +1.7 | 0.002 | −1.7 | 0.004 |
TM4SF18 | transmembrane 4 L six family member 18 | +1.5 | 0.007 | −1.3 | 0.033 |
TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | +1.5 | 0.001 | −1.5 | 0.003 |
TMEM18 | transmembrane protein 18 | +1.5 | 0.008 | −1.4 | 0.028 |
N4BP2L1 | NEDD4 binding protein 2-like 1 | +1.5 | 0.019 | −1.4 | 0.033 |
FMO2 | flavin containing monooxygenase 2 (non-functional) | +1.5 | 0.002 | −1.4 | 0.012 |
RPL37 | ribosomal protein L37 | +1.5 | <0.001 | −1.5 | <0.001 |
FAM184B | family with sequence similarity 184, member B | +1.4 | 0.013 | −1.3 | 0.042 |
LOC100507303 | uncharacterized LOC100507303 | +1.4 | 0.019 | −1.6 | 0.004 |
RNF114 | ring finger protein 114 | +1.3 | 0.016 | −1.3 | 0.030 |
RERE | arginine-glutamic acid dipeptide (RE) repeats | +1.3 | 0.003 | −1.3 | 0.008 |
TUBD1 | tubulin, delta 1 | +1.3 | 0.003 | −1.4 | 0.003 |
ZNF195 | zinc finger protein 195 | +1.3 | 0.003 | −1.3 | 0.002 |
DFFA | DNA fragmentation factor, 45 kDa, alpha polypeptide | +1.3 | 0.010 | −1.2 | 0.016 |
RBBP6 | retinoblastoma binding protein 6 | +1.3 | 0.004 | −1.2 | 0.025 |
NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | +1.3 | 0.011 | −1.2 | 0.022 |
EIF4B | eukaryotic translation initiation factor 4B | +1.3 | 0.017 | −1.3 | 0.015 |
RSBN1 | round spermatid basic protein 1 | +1.2 | 0.003 | −1.2 | 0.016 |
PSIP1 | PC4 and SFRS1 interacting protein 1 | +1.2 | 0.010 | −1.3 | 0.007 |
EIF3G | eukaryotic translation initiation factor 3, subunit G | +1.2 | 0.006 | −1.3 | 0.005 |
PXDC1 | PX domain containing 1 | +1.2 | 0.042 | +1.5 | 0.014 |
BCKDHA | branched chain keto acid dehydrogenase E1, alpha polypeptide | +1.2 | 0.024 | −1.4 | 0.004 |
AKR7A2 | aldo-keto reductase family 7, member A2 | +1.2 | 0.010 | −1.2 | 0.002 |
MRPS2 | mitochondrial ribosomal protein S2 | +1.2 | 0.018 | −1.3 | 0.006 |
RORA | RAR-related orphan receptor A | +1.2 | 0.049 | −1.2 | 0.044 |
RPL36AL | ribosomal protein L36a-like | +1.2 | 0.011 | −1.2 | 0.008 |
PAQR9 | progestin and adipoQ receptor family member IX | −2.0 | <0.001 | +1.4 | 0.027 |
FAM69A | family with sequence similarity 69, member A | −1.8 | 0.001 | +1.7 | <0.001 |
TP53INP2 | tumor protein p53 inducible nuclear protein 2 | −1.8 | <0.001 | +1.3 | 0.017 |
SH3KBP1 | SH3-domain kinase binding protein 1 | −1.8 | 0.002 | +1.3 | 0.035 |
NINJ2 | ninjurin 2 | −1.7 | 0.039 | +2.3 | 0.002 |
MEST | mesoderm specific transcript homolog (mouse) | −1.7 | 0.010 | +2.7 | 0.049 |
ITGB1BP2 | integrin beta 1 binding protein (melusin) 2 | −1.6 | <0.001 | +1.5 | 0.003 |
BPGM | 2,3-bisphosphoglycerate mutase | −1.5 | <0.001 | +1.2 | 0.036 |
MTFP1 | mitochondrial fission process 1 | −1.5 | 0.004 | +1.3 | 0.017 |
MAP2K3 | mitogen-activated protein kinase kinase 3 | −1.5 | 0.003 | +1.3 | 0.021 |
LRRN4CL | LRRN4 C-terminal like | −1.4 | 0.042 | +1.5 | 0.006 |
FBXO9 | F-box protein 9 | −1.4 | <0.001 | +1.3 | 0.001 |
JARID2 | jumonji, AT rich interactive domain 2 | −1.4 | <0.001 | +1.3 | 0.007 |
PRSS23 | protease, serine, 23 | −1.4 | 0.030 | +1.5 | 0.022 |
OLFML2B | olfactomedin-like 2B | −1.4 | 0.049 | +1.7 | 0.031 |
MEMO1 | mediator of cell motility 1 | −1.3 | 0.004 | +1.3 | 0.012 |