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Table 2 Subject baseline characteristics, mean within-group change following intervention with brace and in controls (without brace), and between-group differences in change (pre- and post-intervention)

From: With a biomechanical treatment in knee osteoarthritis, less knee pain did not correlate with synovitis reduction

  Controls (N = 63 randomised, 62 attended 6 week visit) Brace group (N = 63 randomised, 58 attended 6 week visit) Brace group - controls
Variable N in analysis Mean change within group, (95% CI) P-value N in analysis Mean change within group, (95% CI) P-value Mean change within group, (95% CI) P-value
VASNA 58a −0.13 (−0.64 to 0.38) 0.61 56a −1.82 (−2.39 to −1.24) <0.001 1.69 (0.93 to 2.44) <0.001
KOOS pain 61a 1.71 (−1.66 to 5.08) 0.31 57a 8.78 (4.36 to 13.20) <0.001 −7.06 (−12.52 to −1.61) 0.01
Ktrans 48 −0.003 (−0.006 to 0.000) 0.05 39 0.001 (−0.003 to 0.005) 0.63 −0.004 (−0.009 to 0.001) 0.11
RER 48 −0.005 (−0.010 to 0.000) 0.04 39 0.003 (−0.002 to 0.008) 0.19 −0.008 (−0.014 to −0.001) 0.02
RElate 47b −0.102 (−0.280 to 0.076) 0.25 39 0.010 (−0.175 to 0.195) 0.91 −0.112 (−0.367 to 0.142) 0.38
REmax 48 −0.161 (−0.357 to 0.036) 0.11 39 0.045 (−0.166 to 0.256) 0.67 −0.206 (−0.491 to 0.079) 0.15
  1. aNumber of observations for KOOS and VASNA are less than the number attending week 6 visit due to incomplete questionnaires. bDynamic data model error prevented the use of one RElate observation
  2. The reduction in RER represents a reduction in the rate of enhancement and was seen significantly more often in the control group, not in the treatment group