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Table 2 Multivariate analysis of the risk of TKR with delayed anti-TNF treatment after adjusting for confounding factors

From: Delayed anti-TNF therapy increases the risk of total knee replacement in patients with severe rheumatoid arthritis

      

95% CI for HR

Variables

Regression coefficient

SE

Wald

p value

HR

Lower

Upper

Late/early intervention with biological therapy

2.652

0.922

8.27

0.004

8.323

2.256

30.696

RA duration

−0.05

0.08

0.391

0.532

0.951

0.813

1.113

Methotrexate (yes/no)

−1.086

0.446

5.917

0.015

0.338

0.141

0.81

Leflunomide (yes/no)

−2.158

1.228

3.083

0.079

0.116

0.01

1.283

Cyclosporine (yes/no)

−0.54

0.602

0.807

0.369

0.583

0.179

6.034

Sulfasalazine (yes/no)

0.731

0.544

1.803

0.179

2.077

0.715

6.034

RA diagnosis age

−0.104

0.021

0.425

0.515

0.986

0.946

1.028

sex (female/male)

−0.11

0.557

0.039

0.843

0.896

0.301

2.668

Body mass index (kg/m2)

0.017

0.059

0.086

0.769

1.018

0.906

1.143

Diabetes

−0.416

0.805

0.267

0.605

0.66

0.136

3.197

  1. HR Hazard ratio, CI confidence interval, SE standard error, TKR total knee replacement, RA rheumatoid art hritis, DAS28 disease activity score in 28 joints, TNF tumor necrosis factor