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Table 1 Methodological quality appraisal

From: Objective impairments of gait and balance in adults living with HIV-1 infection: a systematic review and meta-analysis of observational studies

  

Trenkwalder 1992 [46]

Arendt 1994 [47]

Beckley 1998 [50]

Bauer 2005 [7]

Dellepiane 2005 [48]

Simmonds 2005 [49]

Scott 2007 [35]

Richert 2011 [8]

Bauer 2011 [22]

Sullivan 2011 [21]

Erlandson 2012a [10]

Erlandson 2012b [18]

Cohen 2012 [45]

Beans 2013 [43]

Mbada 2013 [44]

Richert 2014 [9]

Erlandson 2014 [12]

1

Research question/objective clearly stated?

N

Y

Y

Y

Y

Y

Y

Y

N

Y

Y

Y

Y

Y

Y

Y

Y

2

Study population clearly specified and defined?

N

N

N

Y

N

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

3

Participation rate of eligible persons at least 50%?

CD

CD

CD

CD

CD

CD

CD

N

CD

CD

Y

Y

Y

Y

CD

N

CD

4

All subjects recruited from similar populations? Eligibility criteria pre-specified and applied uniformly?

NR

N

N

Y

NR

N

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

5

Justification of sample size?

N

N

N

Y

N

N

N

N

N

N

N

N

N

N

N

N

N

6

Exposure(s) measured prior to outcome(s)?a

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

Y

N

7

Sufficient timeframe to see an association between exposure and outcome?a

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

Y

N

8

Different levels of the exposure measured, as related to the outcome?

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

9

Exposure measures clearly defined, valid, reliable, and implemented consistently?

NR

Y

Y

Y

NR

Y

Y

Y

Y

Y

Y

Y

Y

NR

Y

Y

Y

10

Exposure(s) assessed more than once over time?a

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

CD

N

11

Outcome measures clearly defined, valid, reliable, and implemented consistently?

CD

NR

NR

NR

CD

Y

Y

NR

Y

NR

N

N

N

Y

Y

NR

CD

12

Outcome assessors blinded to exposure status?

NR

NR

NR

NR

NR

NR

NR

NR

NR

NR

NR

NR

NR

NR

NR

NR

NR

13

Loss to follow-up after baseline ≤20%?a

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

14

Key potential confounders measured and statistically adjusted for?

N

N

N

Y

N

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

 

Total CAT score /14

1

3

3

7

2

6

7

6

6

6

7

7

7

7

7

8

6

 

Total CAT %

7.14

21.43

21.43

50

14.29

42.86

50

42.86

42.86

42.86

50

50

50

50

50

57.14

42.86

  1. Abbreviations: CD cannot determine, NR not reported
  2. aCross-sectional analyses provide weaker evidence than cohort studies regarding a potential causal relationship between exposures and outcomes. For cross-sectional analyses, the answer to Questions 6, 7, 10 & 13 should be “No”. All studies were cross-sectional, except for Richert 2014 (prospective longitudinal cohort)