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Table 4 Model Statistics assessing the association between Fibromyalgia (FMS) and blood serum C-reactive Protein (CRP) quartile adjusting for Sleep impairment and Mood disturbance in a US adult population, 2005–2006 (N = 52,535)

From: Potential Mediators between Fibromyalgia and C-Reactive protein: Results from a Large U.S. Community Survey

 

Models

Odds Ratio (CI) (p-value)

Crudee

Adjusted for Demographic and Lifestyle Factors (Model 1)f

Model 1 ± Moodg

Model 1 ± Sleeph

Model 1 + Mood & Sleepr

CRP level (mg/L)

1.02 (1.01–1.02) (<.0001*)

1.01 (1.00–1.01) (.004*)

1.01 (1.00–1.01) (.021*)

1.01 (1.00–1.01) (.035*)

1.01 (1.00–1.01) (.031*)

CRP Quartile 1a (ref)

—

—

—

—

—

 Quartile 2b

1.33 (1.09–1.62) (.004*)

1.13 (0.92–1.38) (.243)

1.12 (0.91–1.36) (.287)

1.10 (0.90–1.35) (.357)

1.10 (0.90–1.34) (.363)

 Quartile 3c

1.78 (1.48–2.14) (<.0001*)

1.23 (1.02–1.48) (.032*)

1.20 (1.00–1.45) (.056)

1.18 (0.98–1.43) (.083)

1.18 (0.97–1.42) (.093)

 Quartile 4d

2.50 (2.10–2.97) (<.0001*)

1.35 (1.13–1.62) (.0009*)

1.28 (1.07–1.53) (.007*)

1.26 (1.05–1.51) (.011*)

1.24 (1.03–1.48) (.021*)

Wald X2, p for trendt

118.42, (<.0001*)

17.48, (<.0001*)

11.06, (.0009*)

10.40, (.001*)

8.25, (.004*)

  1. *Significant at p < 0.05
  2. aC-reactive protein .15–.80 mg/L
  3. bC-reactive protein .81–1.80 mg/L
  4. cC-reactive protein 1.81–4.20 mg/L
  5. d C-reactive protein 4.21–250.6 mg/L
  6. tLinear trend
  7. e(R2==.003)
  8. fFull Model adjusted for demographic covariates Age, Gender, Marital Status, Employment, Education level, White Race, and Household Income; Also adjusted for lifestyle covariates Tobacco Use and Current Alcohol consumption (R2 = .031)
  9. gMood disturbance derived from responses to four individual questions regarding frequent mood swings, irritability, fatigue and/or inability to concentrate (R2 = .035)
  10. hSleep impairment derived from responses to four individual questions regarding the frequency of short sleep, fitful sleep, insomnia and/or daytime somnolence (R2 = .037)
  11. r(R2 = .038)