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Table 3 Model Statistics assessing the association between Fibromyalgia (FMS) and blood serum C-reactive Protein (CRP) quartile adjusting for BMI and Comorbidity index in a US adult population, 2005–2006 (N = 52,535)

From: Potential Mediators between Fibromyalgia and C-Reactive protein: Results from a Large U.S. Community Survey

Characteristic

Total

FMS

Non-FMS

Models

Odds Ratio (CI) (p-value)

N (%) / Mean (SD)

Crudee

Adjusted for Demographic and Lifestyle Factors (Model 1)f

Model 1 ± BMIg

Model 1 ± comorbiditiesh

Model 1 ± BMI & comorbiditiesr

CRP level (mg/L)

3.79 (7.22)

5.54 (9.77)

3.75 (7.15)

1.02 (1.01–1.02) (<.0001*)

1.01 (1.00–1.01) (.004*)

1.01 (1.00–1.01) (.059)

1.00 (.997–1.01) (.267)

1.00 (.997–1.01) (.279)

CRP Quartile 1a (ref)

14,516 (27.6%)

192 (17.1%)

14,324 (27.9%)

—

—

—

—

—

 Quartile 2b

12,221 (23.3%)

214 (19.0%)

12,007 (23.4%)

1.33 (1.09–1.62) (.004*)

1.13 (0.92–1.38) (.243)

1.07 (0.88–1.32) (.473)

1.04 (0.85–1.28) (.686)

1.03 (0.84–1.27) (.750)

 Quartile 3c

12,755 (24.3%)

297 (26.4%)

12,458 (24.2%)

1.78 (1.48–2.14) (<.0001*)

1.23 (1.02–1.48) (.032*)

1.12 (0.92–1.37) (.244)

1.08 (0.89–1.30) (.452)

1.06 (0.87–1.29) (.576)

 Quartile 4d

13,043 (24.8%)

422 (37.5%)

12,621 (24.6%)

2.50 (2.10–2.97) (<.0001*)

1.35 (1.13–1.62) (.0009*)

1.17 (0.96–1.42) (.120)

1.10 (0.92–1.32) (.310)

1.07 (0.88–1.30) (.510)

Wald X2, p for trendt

   

118.42, (<.0001*)

17.48, (<.0001*)

4.02, (.045*)

3.44, (.064)

1.23, (.269)

  1. *Significant at p < 0.05
  2. aC-reactive protein.15–.80 mg/L
  3. bC-reactive protein.81–1.80 mg/L
  4. cC-reactive protein 1.81–4.20 mg/L
  5. dC-reactive protein 4.21–250.6 mg/L
  6. tLinear trend
  7. e (R2==.003)
  8. fFull Model adjusted for demographic covariates Age, Gender, Marital Status, Employment, Education level, White Race, and Household Income; Also adjusted for lifestyle covariates Tobacco Use and Current Alcohol consumption (R2 = .031)
  9. g(R2 = .031)
  10. hModel adjusted for Comorbidity index; index included diabetes, other endocrine disorders (thyroid, Addison’s, and Cushing’s disease), kidney disease, respiratory conditions (asthma, emphysema, chronic obstructive pulmonary disorder, bronchitis), osteoarthritis, heart disease, liver disease, autoimmune disorders (defined as having any diagnoses of immune disease, lupus, or rheumatoid arthritis), sleep apnea, irritable bowel syndrome, allergies or frequent sinusitis, or frequent recurrent headache (R2 = .041)
  11. r(R2 = .041)