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Table 1 Summary of the studies on HLA-B27 antigen prevalence in SpA and the normal population in Middle Eastern and Arab Countries

From: HLA B27 antigen in Middle Eastern and Arab countries: systematic review of the strength of association with axial spondyloarthritis and methodological gaps

Country Sample Size SpA Sample Size (Control) Prevalence in Population Prevalence in SpA Prevalence in AS OR AS/GP [95% CI] Reference
Algeria 129 AS (ESSG and NY) 76 healthy blood donors 4%   69% 54.14 [16.09–182.18] [17]
Egypt   380 normal individuals 4.7%     [18]
Egypt 75 SpA (ESSG) including 34 AS    58.7%    [19]
Egypt   100 healthy controls 1%     [20]
Iraq 25 AS   2.1%   84%   [21]
Iran 60 AS 430 healthy blood donors 3.95%   66.67% 48.59 [23.57–100.17] [22]
Iran 119 AS     68.91%   [23]
Iran 98 AS (NY)     73.4%   [24]
Israel 38 AS 456 normal individuals 3%   79%   [25]
Jordan 22 AS (NY)     75%   [26]
Jordan / Qatar 129 AS 2579 healthy individuals 2.4%   72.22% 104.87 [66.21–166.11] [12]
Kuwait 58 SpA (27 AS)    69.43% 82.56%   [27]
Kuwait 35 SpA + AS patients 544 controls 4% 25.7%   8.21 [3.44–19.60] [28]
Lebanon 105 SpA (ESSG)
24 AS (NY)
841 Rheumatolgy patients 1.44% 13.85% 26.32% 24.46 [7.78–68.19] [29]
Morocco 46 AS + coxitis 183 healthy controls 6.16%   58.70% 22.09 [9.48–51.49] [30]
Morocco 49 SpA (Amor and ESSG)     67%   [31]
Oman   321 healthy 0.3%     [32]
Qatar 119 AS (NY)     74%   [33]
Saudi Arabia 12 AS     66.67%   [34]
Syria 50 AS (NY) 217 healthy controls 1.4%   60% 105.64 [29.98–381.87] [35]
Tunisia 365 AS and/or BD 124 controls 3.2%   42.9%   [36]
Tunisia 100 AS (NY) 100 healthy controls 3%   62% 52.75 [15.61–178.31] [37]
Tunisia 50 AS (Amor / ESSG)     69%   [38]
Turkey 112 AS (NY) 55 controls 2.8–6.8%   70% 29.82 [9.99–89.05] [39]
Turkey 216 AS (67 analyzed)     91%   [40]
UAE   760 healthy 6.4%     [41]
UAE 17 AS     56%   [42]
  1. AS Ankylosing Spondylitis, BD Behcet’s disease, CI Confidence Interval, ESSG European Spondyloarthropathy Study Group analysis, GP General Population, NY New York criteria, OR Odds Ratio, SpA Spondyloarthritis