Fig. 1

Simulation of serum CTX (sCTX) inhibition in the OCEAN study. Plasma ONO-5334 concentrations in postmenopausal women were measured in the MAD study [31]. Plasma ONO-5334 concentrations at doses of 50 mg BID, 100 mg QD and 300 mg QD were converted into simulated sCTX inhibition using a sigmoidal Emax model from a PK/PD study [29]. Simulated sCTX inhibition over 24 h for doses and regimens used in the OCEAN study (100 mg QD, 300 mg QD, and 50 mg BID) were then calculated [16]. Data for 100 mg QD is used as an illustrative example. BMD: bone mineral density