Fig. 1

Oligomycin can induce joint swelling and inflammatory changes in the synovial tissue. a Knee joint swelling as an indicator of inflammation is estimated from joint width (as described in Methods). Values are mean ± SEM (n = 5). *P ≤ 0.005 and **P ≤ 0.001 vs contralateral vehicle-injected knees. b Representative images of synovial tissue stained with hematoxylin and eosin from each group of study. c Semi-quantitative score of pathological alterations in synovial tissue as described in Methods. Data represent mean ± SEM (n = 5 independent samples for each condition). *P ≤ 0.05 vs contralateral vehicle-injected knees. d Percentage of PMN was analyzed as described in Methods. Values are mean ± SEM (n = 5 independent synovial tissues for each condition). *P ≤ 0.05 vs contralateral vehicle-injected knees. LPS, lipopolysaccharide; OLI, oligomycin