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Table 3 Summary of the collected data displaying distribution of the parameters investigated in the group with implant survival/preservation and the group in whom the implant was removed

From: Factors influencing treatment success of negative pressure wound therapy in patients with postoperative infections after Osteosynthetic fracture fixation

Variable

Description

Survival of the implant until bony consolidationa

p-valueb

Yes

No

n

Mean or %

SD

n

Mean or %

SD

Gender

Male

38

80.9

 

37

64.9

 

0.0712

Female

9

19.1

 

20

35.1

  

Age

 

47

55.5

18.5

57

52.1

18.9

0.3006

Stay at ICU

days

47

4.5

6.5

57

3.1

5.5

0.4337

Initial procedure

Open

45

95.7

 

1

1.8

 

0.5881

 

Closed

2

4.3

 

56

98.2

  

Tissue damage

Open Grade 0-2

7

14.9

 

11

19.3

 

0.042

Open Grade 3-4

2

4.3

 

11

19.3

  

Closed

38

80.9

 

35

61.4

  

Identification of a

Yes

43

91.5

 

48

84.2

 

0.2640

microbial strain

No

4

8.5

 

9

15.8

  

Presence of a bacterial mixture

Yes

5

10.6

 

15

26.3

 

0.0413

No

38

80.8

 

33

57.9

  

No detectable germ

4

8.5

 

9

15.8

  

Change in microbial strain during treatment

Yes

40

85.1

 

40

70.2

 

0.0721

No

7

14.9

 

17

29.8

  

Gram Stain

Positive

34

72.3

 

39

68.4

 

0.8615

Negative

8

17.0

 

10

17.5

  

None

5

10.6

 

8

14.0

  

Bacterial metabolism

Aerobic

3

6.4

 

4

7.0

 

0.2172

Anaerobic

1

2.1

 

2

3.5

  

Facultative anaerobic

38

80.9

 

37

64.9

  

Facultative aerobic

0

0.0

 

5

8.8

  

No detectable germ

5

10.6

 

9

15.8

  

Bacterial load

Plentiful

10

21.3

 

17

29.8

 

0.7030

Numerous

17

36.2

 

15

26.3

  

Sporadic

13

27.7

 

14

24.6

  

Enrichment

2

4.3

 

2

3.5

  

No detectable germ

5

10.6

 

9

15.8

  

Number of lavages until eradication

sponge changes 0

23

48.9

 

27

47.4

 

0.6821

sponge changes 1

13

27.7

 

13

22.8

  

sponge changes 2

4

8.5

 

9

15.8

  

sponge changes ≥3 times

7

14.9

 

4

7.0

  

Never be eradicated

0

0.0

 

4

7.0

 

CRP Initial

[mg/l]

45

81.5

94.1

50

72.6

85.1

0.7201

CRP Maximum

[mg/l]

47

147.6

102.6

52

115.2

95.2

0.2187

CRP Discharge

[mg/l]

46

23.2

39.2

53

24.9

32.9

0.6668

CRP Discharge

≤20 mg/l

34

73.9

 

35

66.0

 

0.5113

>20 mg/l

12

26.1

 

18

34.0

  

Time Point of Infection

Early

36

76.6

 

27

48.2

 

0.0032

Late

11

23.4

 

29

51.8

  

Extent of Infection

Superficial

0

0.0

 

2

3.5

 

0.4998

Deep

47

100.0

 

55

96.5

  

Metabolic diseasec

Yes

8

17.0

 

9

15.8

 

0.8657

No

39

82.0

 

48

84.2

  

Re-infection

Yes

14

29.8

 

23

40.4

 

0.3951

No

33

70.2

 

34

59.6

  

Curing the Infection

Yes

40

85.1

 

35

61.4

 

0.0086

No

7

14.9

 

22

38.6

  
  1. SD = standard deviation, an total = 106, missing data on implant survival until bony consolidation n = 2, b in all analysis two-tailed tests with a significance level of 0.05 were used, c metabolic diseases = kidney diseases, liver diseases and diabetes mellitus