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Table 1 List of influencing parameters and outcome parameters defined in this study

From: Factors influencing treatment success of negative pressure wound therapy in patients with postoperative infections after Osteosynthetic fracture fixation

Influencing parameters
(Independent variables)
Patient parameters:
sex, age, co-morbidities, metabolic diseases (kidney diseases, liver diseases, diabetes mellitus)
Infection parameters:
initial C-reactive protein (CRP), maximum CRP, discharge CRP (≤ 20 mg/l blood versus >20 mg/l)a, time of infection, extent of infection (superficial/deep), time point of infection (early [detected up to 4 weeks after surgery] or late onset [detected more than four weeks after surgery]), soft-tissue damage (according to the Tscherne and Oestern classification)
Germal parameters:
bacterial mixture, identification of bacteria, change in microbial strain during treatment, gram stain, bacterial metabolism (aerobic/anaerobic), bacterial load (Group 1 – very high contamination, Group 2- numerous bacteria, Group 3-isolated bacteria, Group 4-bacteria detectable after enhancement)
Treatment parameters:
Intensive care unit-stay, number of lavages until eradication, re-infection
Outcome parameters (Dependent variables) • cure of infection
• type of wound closure
• preservation or survival of the implant
  1. aCRP-discharge’ was calculated as CRP ≤20 mg/l blood versus >20 mg/l blood at the time of discharge or a change in the infecting bacterial species under therapy