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Fig. 3 | BMC Musculoskeletal Disorders

Fig. 3

From: Early anti-inflammatory intervention ameliorates axial disease in the proteoglycan-induced spondylitis mouse model of ankylosing spondylitis

Fig. 3

Early anti-inflammatory intervention ameliorates axial disease progression. a Penetrance (percent of affected inter-vertebral joints within all inter-vertebral joints scored in the same spine) and the histological scores of b inflammation, c IVD destruction, d bone erosion, e cartilage damage, and f excessive tissue formation. Vehicle (open circle. 6.5–8 weeks, N = 5; 6.5–12 weeks, N = 7) and ETN + PRD (filled circle, 6.5–8 weeks, N = 7; 6.5–12 weeks, N = 8). Each symbol represents one mouse in the group and the results are presented as mean ± SD. Symbols in dashed boxes indicate mice with minimal axial disease. The statistical significance of data was analysed by Mann-Whitney analysis

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