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Table 7 Number of patients experiencing solicited local reactions at the injection site

From: Efficacy and safety of single injection of cross-linked sodium hyaluronate vs. three injections of high molecular weight sodium hyaluronate for osteoarthritis of the knee: a double-blind, randomized, multi-center, non-inferiority study

 

HMWHA

XLHA

P-value

N = 146 (%)

N = 139 (%)

After 1st Injection

58 (39.7)

52 (37.4)

0.69

 Redness

27 (18.5)

21 (15.1)

0.45

 Swelling

13 (8.9)

10 (7.2)

0.60

 Pain

38 (26)

44 (31.7)

0.29

 Warmth

23 (15.8)

23 (16.5)

0.86

After 2nd Injection

43 (29.9)

40 (29.4)

0.93

 Redness

18 (12.5)

16 (11.8)

0.85

 Swelling

6 (4.2)

5 (3.7)

0.83

 Pain

30 (20.8)

27 (19.9)

0.84

 Warmth

16 (11.1)

13 (9.6)

0.67

After 3rd Injection

38 (27.1)

40 (29.4)

0.68

 Redness

17 (12.1)

14 (10.3)

0.63

 Swelling

11 (7.9)

11 (8.1)

0.94

 Pain

31 (22.1)

34 (25)

0.58

 Warmth

12 (8.6)

17 (12.5)

0.29