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Table 7 Number of patients experiencing solicited local reactions at the injection site

From: Efficacy and safety of single injection of cross-linked sodium hyaluronate vs. three injections of high molecular weight sodium hyaluronate for osteoarthritis of the knee: a double-blind, randomized, multi-center, non-inferiority study

  HMWHA XLHA P-value
N = 146 (%) N = 139 (%)
After 1st Injection 58 (39.7) 52 (37.4) 0.69
 Redness 27 (18.5) 21 (15.1) 0.45
 Swelling 13 (8.9) 10 (7.2) 0.60
 Pain 38 (26) 44 (31.7) 0.29
 Warmth 23 (15.8) 23 (16.5) 0.86
After 2nd Injection 43 (29.9) 40 (29.4) 0.93
 Redness 18 (12.5) 16 (11.8) 0.85
 Swelling 6 (4.2) 5 (3.7) 0.83
 Pain 30 (20.8) 27 (19.9) 0.84
 Warmth 16 (11.1) 13 (9.6) 0.67
After 3rd Injection 38 (27.1) 40 (29.4) 0.68
 Redness 17 (12.1) 14 (10.3) 0.63
 Swelling 11 (7.9) 11 (8.1) 0.94
 Pain 31 (22.1) 34 (25) 0.58
 Warmth 12 (8.6) 17 (12.5) 0.29