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Table 6 Adverse drug reactions

From: Efficacy and safety of single injection of cross-linked sodium hyaluronate vs. three injections of high molecular weight sodium hyaluronate for osteoarthritis of the knee: a double-blind, randomized, multi-center, non-inferiority study

Adverse Drug Reactions HMWHA XLHA P-value
N = 146 N = 139
Injection site pruritus 1 (1) 1 (1)A 1.00
Pain 0 (0) 1 (2)A 0.49
Swelling 0 (0) 1 (1) 0.49
Injection site hemorrhage 0 (0) 1 (1) 0.49
Joint swelling 0 (0) 1 (1) 0.49
Erythema 0 (0) 2 (2)A 0.24
Total number 1 (1) 7 (8) 0.03
  1. Data are number of patients experiencing adverse drug reaction and the numbers in parenthesis are number of events
  2. A, In XLHA group, 3 adverse drug reactions (each event of injection site pruritus, pain, and erythema) occurred after placebo injection, which preceded XLHA injection