Efficacy and safety of single injection of cross-linked sodium hyaluronate vs. three injections of high molecular weight sodium hyaluronate for osteoarthritis of the knee: a double-blind, randomized, multi-center, non-inferiority study

Table 3 Responder rate (Per-protocol Set)

	HMWHA	XLHA	P-value^A
	N = 111 (%)	N = 97 (%)	P-value^A
Decrease in weight-bearing pain ≥ 20 mm or ≥ 40% improvement
Visit 5	52 (46.85)	46 (47.42)	0.93
Visit 6	66 (59.46)	70 (72.16)	0.05
Visit 7	76 (68.47)	73 (75.26)	0.28
OMERACT-OARSI response
Visit 5	38 (34.23)	28 (28.87)	0.41
Visit 6	48 (43.24)	47 (48.45)	0.45
Visit 7	55 (49.55)	57 (58.76)	0.18

ISSN: 1471-2474