Reduction of the Serum Levels of a Specific Biomarker of Cartilage Degradation (Coll2-1) by Hyaluronic Acid (KARTILAGE® CROSS) Compared to Placebo in Painful Knee Osteoarthritis Patients: the EPIKART Study, a Pilot Prospective Comparative Randomized Double Blind Trial

Table 5 Variation of serum Coll2-1 between D-10 and D90 in the PP population

	IAHA N = 35	Saline solution N = 31	P value	Test
Serum Coll2-1 at D-10	859.2 ± 396.6	763.7 ± 389.8	0.3288	ANOVA
Serum Coll2-1 at D90	745.9 ± 353.1	767.4 ± 204.0	0.7674	ANOVA
Adjustment on basal value	−82.2 ± 45.6	−31.5 ± 48.5	0.4500 0.0057**	ANCOVA Wilcoxon^a
Reduction of at least 10 nmol/l	57.1%	29.0%	0.0217*	Chi-square test

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