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Table 5 Variation of serum Coll2-1 between D-10 and D90 in the PP population

From: Reduction of the Serum Levels of a Specific Biomarker of Cartilage Degradation (Coll2-1) by Hyaluronic Acid (KARTILAGE® CROSS) Compared to Placebo in Painful Knee Osteoarthritis Patients: the EPIKART Study, a Pilot Prospective Comparative Randomized Double Blind Trial

  IAHA
N = 35
Saline solution
N = 31
P value Test
Serum Coll2-1 at D-10 859.2 ± 396.6 763.7 ± 389.8 0.3288 ANOVA
Serum Coll2-1 at D90 745.9 ± 353.1 767.4 ± 204.0 0.7674 ANOVA
Adjustment on basal value −82.2 ± 45.6 −31.5 ± 48.5 0.4500
0.0057**
ANCOVA
Wilcoxona
Reduction of at least 10 nmol/l 57.1% 29.0% 0.0217* Chi-square test
  1. aShapiro-Wilk normality test < 0.0001, basal value was used as covariate
  2. **p < 0.01, *p < 0.05