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Table 4 Variation of serum Coll2-1 between D-10 and D90 in the FAS population without handling the missing values

From: Reduction of the Serum Levels of a Specific Biomarker of Cartilage Degradation (Coll2-1) by Hyaluronic Acid (KARTILAGE® CROSS) Compared to Placebo in Painful Knee Osteoarthritis Patients: the EPIKART Study, a Pilot Prospective Comparative Randomized Double Blind Trial

  IAHA
N = 40 at D-10
N = 37 at D90
Saline solution
N = 41 at D-10
N = 35 at D90
P value Test
Serum Coll2-1 at D-10 840.3 ± 375.8
(N = 40)
766.1 ± 359.2
(N = 41)
0.3663 ANOVA
Serum Coll2-1 at D90 745.4 ± 343.5
(N = 37)
782.3 ± 233.7
(N = 35)
0.5975 ANOVA
Adjustment on basal value −80.2 ± 44.1 −14.6 ± 45.3 0.3053
0.0030**
ANCOVA
Wilcoxona
Reduction of at least 10 nmol/l 56.8% 28.6% 0.0158* Chi-square test
  1. aShapiro-Wilk normality test < 0.0001, basal value was used as covariate
  2. **p < 0.01, *p < 0.05