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Table 4 Variation of serum Coll2-1 between D-10 and D90 in the FAS population without handling the missing values

From: Reduction of the Serum Levels of a Specific Biomarker of Cartilage Degradation (Coll2-1) by Hyaluronic Acid (KARTILAGE® CROSS) Compared to Placebo in Painful Knee Osteoarthritis Patients: the EPIKART Study, a Pilot Prospective Comparative Randomized Double Blind Trial

 

IAHA

N = 40 at D-10

N = 37 at D90

Saline solution

N = 41 at D-10

N = 35 at D90

P value

Test

Serum Coll2-1 at D-10

840.3 ± 375.8

(N = 40)

766.1 ± 359.2

(N = 41)

0.3663

ANOVA

Serum Coll2-1 at D90

745.4 ± 343.5

(N = 37)

782.3 ± 233.7

(N = 35)

0.5975

ANOVA

Adjustment on basal value

−80.2 ± 44.1

−14.6 ± 45.3

0.3053

0.0030**

ANCOVA

Wilcoxona

Reduction of at least 10 nmol/l

56.8%

28.6%

0.0158*

Chi-square test

  1. aShapiro-Wilk normality test < 0.0001, basal value was used as covariate
  2. **p < 0.01, *p < 0.05
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