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Fig. 8 | BMC Musculoskeletal Disorders

Fig. 8

From: Glutamate signaling through the NMDA receptor reduces the expression of scleraxis in plantaris tendon derived cells

Fig. 8

Results of 24 h of Dexamethasone exposure on gene expression (qPCR) of Gls a and Got1 b, levels of free glutamate (glutamate assay) c and the protein content (densitometry of western blots) of NMDAR1 d in response to dexamethasone (Dex) exposure at concentrations from 1 nM to 1000 nM. Gls and Got1 mRNA is reduced in a dose dependent manner a, b. Glutamate levels are decreased at 10 nM and 100 nM of dexamethasone. No changes can be observed for NMDAR1 c. Asterisks mark significance for outcome in relation to the control (CTR). Error bars show standard deviation. (* p < 0.05; ** p < 0.01; *** p < 0.001; n.s. = not significant). n = 3

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