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Table 2 Association between TSH categories and hip or knee replacement due to osteoarthritis

From: Incidence of total hip or knee replacement due to osteoarthritis in relation to thyroid function: a prospective cohort study (The Nord-Trøndelag Health Study)

TSH (mU/L)

Persons (n)

Cases (n)

HRa

(95% CI)

HRb

(95% CI)

HRc

(95% CI)

THR

  < 0.50

908

21

0.98

(0.63–1.53)

0.99

(0.64–1.53)

1.04

(0.63–1.69)

 0.50–1.49

17675

411

0.93

(0.81–1.08)

1.07

(0.93–1.24)

1.09

(0.94–1.28)

 1.5–2.49

13228

359

1

Reference

1

Reference

1

Reference

 2.5–3.49

3773

105

0.98

(0.79–1.22)

0.85

(0.68–1.05)

0.88

(0.69–1.11)

  > 3.5

2307

82

1.22

(0.96–1.55)

0.96

(0.76–1.22)

0.98

(0.75–1.27)

TKR

  < 0.50

908

14

1.26

(0.73–2.16)

1.32

(0.76–2.26)

1.33

(0.74–2.4)

 0.50–1.49

17675

224

0.97

(0.80–1.18)

1.15

(0.95–1.40)

1.12

(0.91–1.37)

 1.5–2.49

13228

191

1

Reference

1

Reference

1

Reference

 2.5–3.49

3773

64

1.12

(0.84–1.48)

0.94

(0.71–1.25)

0.88

(0.65–1.20)

  > 3.5

2307

45

1.24

(0.90–1.72)

0.98

(0.70–1.35)

0.87

(0.61–1.25)

  1. (THR total hip replacement, TKR total knee replacement)
  2. aUnadjusted
  3. bAdjusted for age, sex, BMI and smoking
  4. cAdjusted for age, sex, BMI, smoking, physical activity and diabetes