Skip to main content
Fig. 4 | BMC Musculoskeletal Disorders

Fig. 4

From: IL-10 ameliorates TNF-α induced meniscus degeneration in mature meniscal tissue in vitro

Fig. 4

Immunostaining of the aggrecan cleavage product NITEGE of meniscal explants after 3 days of incubation with TNF-α [10 ng/ml] and IL-10 [10 ng/ml]. There was an increase in NITEGE-staining (red fluorescence) in TNF-α-treated samples c in comparison to control tissues a and sole IL-10 stimulation (b). IL-10 was able to reduce TNF-α-dependent formation of NITEGE fragments (d). Cellular nuclei are counterstained using bisbenzimide (blue fluorescence). Scale bar = 50 μm

Back to article page