Fig. 3From: Immunogenicity and immunomodulatory effects of the human chondrocytes, hChonJImmunogenecity and immunosuppressive effect of hChonJ. The immunogenicity and immunosuppressive effects of allogeneic hChonJ cells were assessed using an MLR assay with allogeneic PBMCs that were isolated from a MHC mismatched donor. The proliferation of responder PBMCs was measured with 0.5 μCi 3H-thymidine. hChonJ cells did not stimulate allogeneic T cell proliferation (a) and significantly suppressed allogeneic T cell proliferation in a dose-dependent fashion (b). Bars represented the change of 3H-thymidine uptake in comparison with an allogeneic MLR control (100%). Mean values from 4 independent experiments are illustrated (Mean ± SE)Back to article page