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Table 4 Results of the meta-analysis concerning subjective symptoms

From: Is hydroxychloroquine effective in treating primary Sjogren’s syndrome: a systematic review and meta-analysis

 

Hydroxychloroquine

Placebo

Total, dry mouth

 No. of studies

3

2

 Total patients observed

96

59

 No. of improved

48

25

 Pooled proportion, % (95% CI)

47.9 (38.2 to 57.8)

42.6 (30.6 to 55.1)

 I2 Inconsistency

22.6

-

Total, dry eyes

 No. of studies

3

2

 Total patients observed

97

59

 No. of improved

49

26

 Pooled proportion, % (95% CI)

50.6 (40.8 to 60.3)

46.4 (28.8 to 64.5)

 I2 Inconsistency

48.4

-

Total, pain

 No. of studies

3

2

 Total patients observed

88

51

 No. of improved

43

18

 Pooled proportion, % (95% CI)

48.9 (38.7 to 59.1)

35.8 (23.5 to 49.0)

 I2 Inconsistency

0

-

Total, fatigue

 No. of studies

3

2

 Total patients observed

94

56

 No. of improved

30

19

 Pooled proportion, % (95% CI)

35.9 (19.5 to 54.2)

51.4 (7.7 to 93.8)

 I2 Inconsistency

63.4

-