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Table 4 Results of the meta-analysis concerning subjective symptoms

From: Is hydroxychloroquine effective in treating primary Sjogren’s syndrome: a systematic review and meta-analysis

  Hydroxychloroquine Placebo
Total, dry mouth
 No. of studies 3 2
 Total patients observed 96 59
 No. of improved 48 25
 Pooled proportion, % (95% CI) 47.9 (38.2 to 57.8) 42.6 (30.6 to 55.1)
 I2 Inconsistency 22.6 -
Total, dry eyes
 No. of studies 3 2
 Total patients observed 97 59
 No. of improved 49 26
 Pooled proportion, % (95% CI) 50.6 (40.8 to 60.3) 46.4 (28.8 to 64.5)
 I2 Inconsistency 48.4 -
Total, pain
 No. of studies 3 2
 Total patients observed 88 51
 No. of improved 43 18
 Pooled proportion, % (95% CI) 48.9 (38.7 to 59.1) 35.8 (23.5 to 49.0)
 I2 Inconsistency 0 -
Total, fatigue
 No. of studies 3 2
 Total patients observed 94 56
 No. of improved 30 19
 Pooled proportion, % (95% CI) 35.9 (19.5 to 54.2) 51.4 (7.7 to 93.8)
 I2 Inconsistency 63.4 -