Mucin 1, a signal transduction membrane-bound mucin, is present in human disc tissue and is downregulated in vitro by exposure to IL-1ß or TNF-α

Table 1 Demographic features for subjects whose disc tissue was evaluated with immunohistochemistry or whose tissue or cells were utilized for molecular analysis

Subject number	Age	Thompson score	Vertebral level	Specimen type^a	Experimental use^b
1	34	I	Lumbar	CHTN	Mol
2	30	II	L3-4	CHTN	Mol
3	30	II	L3-4	CHTN	Mol
4	54	II	L4-5	Surgical specimen	Mol
5	21	II	L5-S1	Surgical specimen	Mol
6	40	II	L4-5	Surgical specimen	Mol
7	41	V	L4-5	Surgical specimen	Mol
8	57	V	C6-7	Surgical specimen	Mol
9	72	V	L4-S1	Surgical specimen	Mol
10	1	I	Lumbar	CHTN	Imm
11	Newborn	I	Lumbar	CHTN	Imm
12	21	II	L5-S1	Surgical specimen	Imm
13	24	II	L5-S1	Surgical specimen	Imm
14	41	II	L5-S1	Surgical specimen	Imm
15	29	III	L5-S1	Surgical specimen	Imm
16	53	III	L5-S1	Surgical specimen	Imm
17	54	III	L4-5	Surgical specimen	Imm
18	58	III	L2-3	Surgical specimen	Imm
19	39	IV	L4-5	Surgical specimen	Imm
20	56	IV	L2-3	Surgical specimen	Imm
21	59	IV	L2-3	Surgical specimen	Imm
22	78	IV	L3-4	Surgical specimen	Imm
23	39	V	L5-S1	Surgical specimen	Imm
24	56	V	L5-S1	Surgical specimen	Imm
25	62	V	L5-S1	Surgical specimen	Imm
26	59	IV	L4-5	Surgical specimen	3D and Mol
27	59	IV	L4-5	Surgical specimen	3D and Mol
28	57	III	C4-5	Surgical specimen	3D and Mol
29	54	IV	L3-4	Surgical specimen	3D and Mol

^a CHTN Cooperative Human Tissue Network, normal donor specimen, OR surgical specimen, L lumbar, C cervical
^b Imm immunohistochemistry on disc tissue, 3D and Mol cells cultured in 3D and 3D mRNA harvested for microarray analysis, Mol human annulus tissue mRNA harvested for microarray analysis

ISSN: 1471-2474