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Fig. 3 | BMC Musculoskeletal Disorders

Fig. 3

From: Influence of subject discontinuation on long-term nonvertebral fracture rate in the denosumab FREEDOM Extension study

Fig. 3

Observed fracture incidence vs Kaplan-Meier estimated fracture incidence in sensitivity analyses. We compared the observed cumulative fracture incidence in crossover and long-term denosumab-treated subjects up to Extension year 5 (year 8 overall) vs the Kaplan-Meier estimated fracture incidence using a multiple imputation approach with the assumption that subjects who withdrew had double the fracture risk after study discontinuation compared with those who remained on the study. N is the number of subjects who remained at risk at the beginning of each year

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